胃痞消对实验性大鼠慢性萎缩性胃炎的作用  

Effect of Weipixiao on chronic atrophic gastritis rats with spleen deficiency

作　　者：潘华峰 赵霞[2] 鞠晓云[2] 范乃兵[2] 

机构地区：[1]广州中医药大学实验动物中心,广东广州510405 [2]南京中医药大学儿科教研究室,江苏南京210029

出　　处：《中国中西医结合消化杂志》2005年第5期287-289,共3页Chinese Journal of Integrated Traditional and Western Medicine on Digestion

基　　金：广东省教育厅自然科学基金资助项目(Z0203);广东省科技厅自然科学基金资助项目(04010050)

摘　　要：[目的]探讨健脾化瘀解毒复方胃痞消对慢性萎缩性胃炎(CAG)模型大鼠胃黏膜上皮细胞病理改变的影响。[方法]采用致癌化学物N-甲基-N’-硝基-N亚硝基胍配合饥饱失常、耗气泻下法建立CAG脾虚模型。采用免疫组化法检测胃黏膜萎缩、肠上皮化生等病理变化。[结果]模型对照组胃黏膜萎缩、肠化生均较正常组明显增加(P<0.01);胃痞消预防组、高、中、低剂量组较模型对照组明显降低(均P<0.01)。[结论]胃痞消防治CAG的作用机制与其通过降低胃黏膜萎缩、肠化生及两者并见出现率,逆转已发生的萎缩,从而阻止其发生癌变。[Objective] To explore the effect of Weipixiao, a compound of invigorating spleen and removing blood stasis and toxic substance, on pathologic changes of gastric mucosal cells in preventing and treating chronic atrophic gastritis（CAG）. [Methods] CAG model with syndrome of spleen deficiency was established by N-methyl-N＇-nitro-N-nitrosoguanidine（MNNG） and irregular fasting combined with purgative drugs. Changes of gastric mucous atrophy and intestinal metaplasia in gastric mucous were observed with HE technique and immunohistochemical stain. [Results] Gastric mucous atrophy and intestinal metaplasia in gastric mucous of the model group were more than those of the normal group （P〈0. 01）; but decreased in the three different dosage of Weipixiao groups （P〈0. 01 ）. [Conclusion]fhe mechanism of Weipixiao is related to reducing the occurrence ratio of atrophy and intestinal metaplasia in the gastric mucous, reversing the atrophy of gastric mucous so as to impede ratio of carcinogenesis.

关 键 词：胃炎 萎缩性 健脾化瘀解毒法 胃痞消 胃黏膜萎缩 

分 类 号：R573.3[医药卫生—消化系统]