梗阻性黄疸患者血清中sIL-2R的变化与免疫功能  

Relationship between serum sIL-2R changes and immune function in patients with obstructive jaundice

作　　者：尹兰宁[1] 宋爱琳[1] 寇治民[1] 

机构地区：[1]兰州大学第二医院 普外科,甘肃兰州730030

出　　处：《兰州大学学报（医学版）》2005年第3期13-15,共3页Journal of Lanzhou University（Medical Sciences）

摘　　要：目的探讨和研究可溶性白细胞介素2受体(sIL-2R)对梗阻性黄疸免疫功能影响。方法收集20例梗阻性黄疸患者的临床资料,对患者血清谷丙转氨酶(ALT)、γ-谷酰胺转移酶(γ-GT)、内毒素(ET)、sIL-2R、T淋巴细胞亚群和免疫球蛋白等进行检验。结果本组资料20例梗阻性黄疸患者与胆结石对照组相比,血清中的sIL-2R在胆道引流前伴随T淋巴细胞亚群水平下降而上升,术后则伴随T淋巴细胞亚群水平的上升而下降,手术前后sIL-2R水平的变化差异具有显著性意义。结论良性梗阻性黄疸时,血清中的sIL-2R的浓度变化对梗阻性黄疸的免疫功能变化具有一定的意义。Objective To study the effects of serum sIL-2R on immune function in patients with obstructive jaundice. Methods The clinical data of 20 patients suffering from obstructive jaundice were collected and their serum ALT, 7-GT, endotoxin, sIL-2R, T-lymphocyte subgroups and immunoglobulins were examined. Results Compared with patients suffering from gall-stone, serum sIL-2R in patients with obstructive jaundice became increased and was accompanied by the decrease of T-lymphocyte subgroups before bile duct drainage, however, it became decreased and was accompanied by the increase of T-lymphocyte subgroups after bile duct obstruction was removed, and there was a significant difference in sIL-2R level before and after operation（P〈0.05）. Conclusion This study indicated that sIL-2R might play a certain role in the immune function of patients with obstructive jaundice.

关 键 词：梗阻性黄疸 免疫功能 可溶性白细胞介素2受体 SIL-2R水平 良性梗阻性黄疸 免疫功能变化 血清 患者 可溶性白细胞介素2受体 T淋巴细胞亚群 谷丙转氨酶(ALT) 谷酰胺转移酶 

分 类 号：R737.9[医药卫生—肿瘤] R575[医药卫生—临床医学]