^(18)F-氟代脱氧葡萄糖应用于肺癌术中导向的实验研究  

The experimental study on radioguided surgery in lung carcinoma using ^(18)F-FDG

作　　者：柳曦[1] 周乃康[1] 孙玉鹗[1] 王钰琦[1] 吴兵[2] 

机构地区：[1]解放军总医院胸外科,北京100853 [2]辽宁省锦州市中心医院胸外科

出　　处：《解放军医学杂志》2005年第10期884-886,共3页Medical Journal of Chinese People's Liberation Army

摘　　要：目的研究放射导向手术(RGS)在肺肿瘤外科中的应用价值。方法根据有无肺转移,40只荷肺腺癌小鼠被随机配对分成两组,并经尾静脉注入200μl(100μCi)18F-氟代脱氧葡萄糖(18F-FDG)。注药后进行体外放免显像、手持型γ探测仪(GDP)体内探测及井型探测仪分析。结果注药后2h肿瘤显像最清晰。井型探测仪显示心脏与肿瘤的放射性分布(%ID/g)高于其他脏器。GDP显示肿瘤/正常组织放射性比值(T/NT)为3·71~13·57(除肿瘤/心脏以外)。肺转移组肺组织的%ID/g及T/NT比值与对照组肺组织相比存在显著性差异(P<0·01)。肺转移癌的T/NT为2·91±0·45。结论肺癌组织能够大量摄取18F-FDG,利用GDP可准确区分肿瘤及正常组织并探测出转移病灶。Objective To investigate the effectiveness of radioguided surgery （RGS） in lung carcinoma by using ^18F-FDG. Methods Forty mice bearing lung adenocarcinoma were divided randomly into two groups according to presence or absence of the lung metastasis. A dose of 200μl （100μCi） of ^18F-FDG was injected via the tail vein. The external radioimmunography was performed after injection. All viscerae and tumor were detected in vivo by means of a hand-held gammaray-detecting probe （GDP）, and the radioactive distribution was analyzed with the well-gammaray detector. Results The tumor images in mice were clear, and the images were best at two hours after injection. The values of %ID/g of tumor and heart obtained by well-gammaray detector were higher than those of other organs. Ratios of tumor/normal tissue （T/NT） except cardiac muscle being detected by GDP ranged from 3.71 to 13.57. There was a significant difference between the radioactivity of lung tissues in lung metastasis group and that of control group （P〈0.01）. T/NT ratios of lung metastasis were 2.91±0.45. Conclusion The uptake of ^18F-FDG by malignancy in the lung is higher than that in normal tissues. It was found that the neoplastic tissues could be differentiated accurately from normal tissues, and small sized metastases could be discerned by using GDP.

关 键 词：肺肿瘤 放射导向手术 放射性同位素 

分 类 号：R734.2[医药卫生—肿瘤]