垂体腺瘤患者血浆神经肽Y与垂体激素水平相关性研究  

Research on the relationship between neuropeptide Y and pituitary hormones in plasma of pituitary adenoma patients

作　　者：甄自刚[1] 马景砲 阎学江[2] 

机构地区：[1]天津医科大学总医院神经外科 [2]天津环湖医院

出　　处：《中华神经外科杂志》2005年第10期612-615,共4页Chinese Journal of Neurosurgery

基　　金：国家自然科学基金项目(项目编号:30471772)

摘　　要：目的探讨垂体腺瘤患者血浆神经肽Y(NPY)与垂体激素之间的相关关系。方法收集82例垂体腺瘤患者及20例对照组空腹静脉血3ml,进行血浆NPY放免测定分析,并与垂体激素水平进行相关分析。初步探讨NPY与部分其他临床指标之间的相关性。结果⑴垂体腺瘤患者、泌乳素细胞腺瘤、生长激素细胞腺瘤、无内分泌功能细胞腺瘤及多分泌功能细胞腺瘤组中血浆NPY与PRL呈负相关。⑵垂体腺瘤患者血浆NPY与ACTH呈正相关。⑶促性腺激素细胞腺瘤中NPY与LH呈正相关而与GH呈负相关。⑷NPY在垂体腺瘤组与对照组中血浆含量明显不同,而且部分不同垂体腺瘤组之间也存在明显差异。⑸全组垂体腺瘤手术后血浆NPY的含量下降。结论NPY参与了垂体腺瘤病理生理中下丘脑-垂体轴许多激素的调节,可能与垂体腺瘤的发生有关。Objective In order to investigate the correlation between neuropeptide Y and pituitary hormones in plasma of pituitary adenoma patients. Methods The 3ml venous blood was collected from 82 patients with pituitary adenoma and 20 normal persons as control in this experiment. The level of NPY in plasma was measured by radio-immunity analysis and the correlation was analyzed between the level of pituitary hormones and NPY in plasma of the patients with pituitary adenoma. In addition, the correlation and difference were discussed elementarily between the NPY and other clinical manifestations. Results （1） There was a negative correlation between the level of PRL and NPY in plasma of the patients with pituitary adenoma, PRL-secreting adenoma, GH-secreting adenoma, nonsecreting pituitary adenoma,polysecreting pituitary adenoma. （2） There was a positive correlation between the level of ACTH and NPY in plasma of the patients with pituitary adenoma. （3） There was a positive correlation between the level of LH and NPY in plasma of the patients with ACTH-secreting adenoma, however, there was a negtive correlation between the level of GH and NPY in this adenoma. （4） It was shown that there was distinctive difference of the level of NPY between the group of pituitary adenoma and the control and in the different types of hypophysoma. （5） It was found that there was distinctive difference of the level of NPY between pre and pro of operation. Conclusions NPY is involved in the regulation of hypothalami-pituitary hormones and the pathology of pituitary adenoma.

关 键 词：血浆神经肽Y 垂体腺瘤 垂体激素 相关性 激素水平 患者 血浆NPY 细胞腺瘤 内分泌功能 血浆含量 

分 类 号：R736.4[医药卫生—肿瘤]