甲胎蛋白异质体对甲胎蛋白不同含量肝癌的诊断意义  

THE DIAGNOSTIC SIGNIFICANCE OF THEDETERMINATION OF ALPHAFETOPROTEIN HETERO-GENEITY IN HEPATIC CARCINOMA WITH DIFFERENTSERUM ALPH A-FETOPROTEIN LEVELS

作　　者：徐建业[1] 李伟道[1] 张静兰[1] 史玲[1] 张仲国 周福康[1] 杨廷碧 陈忠良 艾金惠 

机构地区：[1]重庆市肿瘤研究所

出　　处：《重庆医药》1989年第4期1-2,共2页

摘　　要：本文首次报道对血清AFP＜20ng·ml^(-1)肝癌及肝病患者作甲胎蛋白异质体测定。原发性肝癌组74例，扁豆凝集素（LCA）非结合型AFP（AFP-N-L）_x^-±SD：42.19±28.99％，其中AFP＜20ng·ml^(-1)19例为23.67±35.12％，AFP＜20ng·ml^(-1) 55例48.58±23.73％，前者明显低于后者（p＜0.001）。良性肝病组49例98.14±13.81％，其中AFP＜20ng·ml^(-1)25例95.98±14.45％，AEP＞20ng·ml^(-1) 24例92.3±13.16％，二者无差异。肝癌组明显低于肝病组（P＜0.001）。简略讨论了AFP异质体测定的临床意义。This is the first time to report the determination of AFP heterogeneity ia patients with serum AFP<20ng.ml-1. The percentage of AFP-N-L was significantly lower in 74 patients with primary hepatic carcinoma (Group PHC, x sd : 42.18 ± 28.89%) than in 49 patients with benign liver disease (Group BLD : 94.18± 13.81% p<0.001) . In Group PHC AFP-N-L percentage was significantly lower in patients with serum AFP<20ng,ml-1 (n = 19, 23.67±35.12%) than ill patients with serum AFP>20ng.ml-1 (n = 55, 48.58 ±23.73%, p<0.001) . in Group BLD AFP-N-L percentage was no difference between 25 patients with serum AFP <20ng.ml-1 and 24 patients with serum AFP>20ng.rnl-1. Briefly discussed the clinical sig-nificance of AFP heterogeneity.

关 键 词：肝癌 甲胎蛋白 异质体 AFP 

分 类 号：R735.705[医药卫生—肿瘤]