p21、p27、bcl-2和bax在肺癌组织中表达的意义及相关性研究  

The Expression and Associativity of P21, P27, bcl-2 and bax in Lung Cancer

作　　者：陈公琰[1] 洪璇[1] 李英红[1] 冯占军[1] 

机构地区：[1]哈尔滨医科大学附属肿瘤医院内一科,哈尔滨市150040

出　　处：《中国肿瘤临床》2005年第21期1216-1219,共4页Chinese Journal of Clinical Oncology

基　　金：黑龙江省教育厅科学技术研究项目基金资助(编号:D01-47)

摘　　要：目的:探讨p21、p27、bcl-2、bax蛋白在肺癌中的表达及其临床意义。方法:采用免疫组化S-P法,检测85例肺癌患者及21例良性肺疾病患者术后组织标本中p21、p27、bcl-2、bax的表达。结果:p21、p27、bcl-2、bax蛋白总阳性表达率分别为72.94%、37.65%、61.18%、41.18%。各种蛋白的阳性表达率在肺癌组织与对照组间均存在差异性(P<0.05)。仅bcl-2蛋白表达与肺癌的不同病理类型有关,其中在小细胞肺癌中表达率最高、鳞癌次之、腺癌最低。p27、bcl-2、bax三者的阳性表达随病理分化程度的降低而降低(P<0.05)。p21与bcl-2蛋白的阳性表达与肺癌临床TNM分期有关(P<0.05)。bax蛋白的表达与有无淋巴结转移有关。p27、bcl-2、bax三者之间存在相关性。结论:p21、p27、bcl-2、bax蛋白与肺癌的发生、发展有密切关系。联合检测p21、p27、bcl-2、bax对于临床诊断肺癌及判断病情、预后有重要意义。Objective： To investigate the clinical significance in lung cancer. Methods： expression of P21, P27, bcl-2 and bax protein and their The expression of P21, P27, bcl-2 and bax was detected respectively in 85 patients with lung cancer and 21 with benign pulmonary lesion by the immunohistochemical staining. Result： Positive rate of P21, P27, bcl-2, bax protein expression was 72.94%, 37.65%, 61.18% and 41.18%, respectively. There was a statistically significant difference in positive rates of these protein （P〈0.05）. There was a close correlation between expression of bcl-2 and the histopathological types of lung cancer; the rate of bcl-2 in small cell carcinoma was the highest and that in adeocarcinoma was the lowest. The positive rate of P27, bcl-2 and the bax protein in higher differentiation group was significantly lower than that in lower differentiation group （P〈0.05）. The positive rate of P21 and bcl-2 protein was correlated with the P-TNM stages （P〈0.05）. Only expression of bax protein has relation with the lymph node metastasis. There was a correlation between P27, bcl-2 and the bax protein. Conclusion： The results suggest that P21, P27, bcl-2 and bax protein have relations with the genesis and development of lung cancer. The detection for these proteins will play an important part in clinical diagnosis and prognosis.

关 键 词：肺肿瘤 P21 P27 BCL-2 BAX 

分 类 号：R734.2[医药卫生—肿瘤]