乳腺癌术后放疗晚期放射性肺损伤的临床分析  

Clinical Analysis of Late Pulmonary Injury in Breast Cancer Patients Treated by Postoperation Radiotherapy

作　　者：陈暑波[1] 田野[2] 季永领[2] 杨劲松[2] 陆雪官[2] 

机构地区：[1]无锡市第二人民医院肿瘤科 [2]苏州大学附属第二医院肿瘤放疗科,江苏省苏州市215004

出　　处：《中国肿瘤临床》2005年第21期1224-1226,1230,共4页Chinese Journal of Clinical Oncology

摘　　要：目的:了解乳腺癌根治性手术后放射治疗患者晚期放射性肺损伤的发病情况并探讨其影响因素。方法:分析74例根治/改良根治术后放疗的乳腺癌患者的临床资料,其放疗后随访时间为12～84个月(中位数33.6个月)。采用LENT-SOMA标准,从主观症状和客观体征(X线胸片)两方面研究晚期放射性肺损伤的发生情况,并采用Logistic回归分析其相关的发病因素。结果:晚期放射性肺损伤在主观症状和客观体征方面的发生率分别为16.2%和37.8%。多因素分析表明:患者年龄(>47岁≤)、吸烟史(有和无)、接受化疗周期数(3～6周期和>6周期)晚期放射性肺损伤的发生率分别为23.3%和47.7%(P=0.034)、0和41.2%(P=0.046)、31.0%和62.5%(P=0.022)。结论:晚期放射性肺损伤是乳腺癌术后放疗患者较常见的并发症之一,有一些临床因素会增加该病的发生率。Objective： To assess the prevalence of late pulmonary injury in breast cancer patients treated by postoperation radiotherapy and to identify its potential predictive factors. Methods： Seventyfour radical mastectomy patients were examined prior to and more than 12 months after radiotherapy, its median was 33.6 months. Study the crude rate of late pulmonary injury by LENT-SOMA scales and its potential predictive factors by binary logistic regression of the multivariate analysis. Results： The subjective complains and objective signs in chest films of late pulmonary injury were found in 16.2% and 37.8% patients respectively. Multivariate analysis revealed that the risk of late pulmonary injury was significantly increased in the elder patients （P=0.034） and non-smokers （P=0.046）, whereas more than 6 cycles chemotherapy given after radiotherapy （P=0.022）. Conclusion： The late pulmonary injury is one of the familiar complications after radiotherapy for radical mastectomy, some clinical factors are associated with the increasing incidence of this disease.

关 键 词：乳腺肿瘤 手术 放射疗法 放射性肺损伤 

分 类 号：R737.9[医药卫生—肿瘤]