聚氧化乙烯基-β-环糊精的合成、溶血作用及增溶作用的研究  

Synthesis of hydroxyethyl-β-cyclodextrin and its hemolysis and solubilization

作　　者：宋全道[1] 丁易[2] 

机构地区：[1]山东大学药学院物理化学教研室,山东济南250012 [2]济南市科技信息研究所,山东济南250001

出　　处：《山东大学学报（医学版）》2005年第9期788-790,794,共4页Journal of Shandong University:Health Sciences

摘　　要：目的:合成出聚氧化乙烯基-β-环糊精,并测定其溶血作用和槲皮素的增溶作用。方法:β-环糊精在碱溶液中与环氧乙烷反应生成聚氧化乙烯基-β-环糊精,用红外光谱、核磁共振波谱等方法鉴定合成的产物;用兔全血中分离的血红细胞测定其在体外的溶血作用;用紫外分光光度法测定其对槲皮素的增溶作用。结果:聚氧化乙烯基-β-环糊精溶血作用不仅比β-环糊精显著降低,也明显低于羟丙基-β-环糊精;且对槲皮素的增溶作用显著。结论:聚氧化乙烯基-β-环糊精是一种极具应用潜力的药用辅料。Objective： To synthesize polyoxyethylene-β-cyclodextrin （PE-β-CD） and study its hemolysis in vitro and its effect on the solubilization of quercetin in water. Methods： β-cyclodextrin was used to react on epoxy ethane in alkali solution to obtain polyoxyethylene-β-cyclodextrin which was identified by IR spectrophotometry and ^13C-NMR spectral analysis. The hemolysis was deteated by means of red blood cells isolated from whole rabbit blood and the effect of PE-β-CD on solubilization of quercetin in water was studied by UV spectrophotometry. Result： The hemolytic potential of PE-β-CD was much smaller than that of β-CD, and also smaller than that of HP-β-CD. PE-β-CD also exhibited a remarkable effect on solubilization of quercetin in water. Conclusion： PE-β-CD may well be applied as a novel auxiliary material for injection.

关 键 词：聚氧化乙烯基-β-环糊精 合成 溶血 槲皮素 增溶 

分 类 号：R972.6[医药卫生—药品]