乙醇促进大鼠纹状体隔核抗坏血酸的释放  

ETHANOL INCREASED ASCORBATE RELEASE IN RAT STRIATUMAND THE NUCLEUS ACCUMBENS

作　　者：刘雯[1] 吴春福[1] 刘静[1] 李竹[1] 

机构地区：[1]沈阳药科大学中药药理室

出　　处：《中国药物依赖性通报》1996年第3期156-158,共3页

摘　　要：应用脑内微透析技术结合ＨＰＬＣ－ＥＣＤ法检测显示，乙醇（２．５，５．０ｇ·ｋｇ－１，ｉｐ）显著增加大鼠纹状体和伏隔核抗坏血酸的释放。５．０ｇ·ｋｇ－１乙醇可使纹状体和伏隔核释放峰值达３０％以上，对伏隔核抗坏血酸的影响持续时间长于纹状体。提示脑中抗坏血酸参与乙醇对中枢神经系统的作用。Ethanol(2. 5, 5. 0 g· kg-1, ip) significantly increased ascorbate releasein rat striatum and the nucleus accumbens by using brain dialysis technique coupled tohigh performance liquid chromatography with electrochemical detection. Ethanol 5. 0g· kg-1 increased ascorbate release more than 300 % compared with the baseline in both striatum and nucleus accumbens. The effect of ethanol lasted more in nucleus accumbensthan in striatum. The results suggested that the brain ascorbate be involved in the actionof ethanol in central nervous system.

关 键 词：乙醇 抗坏血酸 纹状体 伏隔核 药理学 

分 类 号：R965[医药卫生—药理学]