近红外光无创伤检测早期肝硬化的实验研究  

Experimental Research on Non-invasive Near-infrared Detection of Early Hepatocirrhosis

作　　者：张晓方[1] 刘建军[1] 谢则平[2] 

机构地区：[1]长江大学医学院预防医学系,荆州434000 [2]华中科技大学生命科学院,武汉430074

出　　处：《生物医学工程学杂志》2005年第4期795-797,共3页Journal of Biomedical Engineering

摘　　要：为评价近红外光无创伤检测早期肝硬化的价值。定期用四氯化碳注射小白鼠制作肝硬化模型。用Runman仪检测肝脏组织血、氧含量,并提取血、氧变化波形,在Matlab软件下进行分析,发现近红外光无创伤检测能灵敏反应早期肝硬化时血、氧含量的变化。早期肝硬化时,血及氧波形节律不规则、自功率谱主频峰位置后移在1.0～1.5Hz间,且出现多峰。表明近红外光无创伤检测早期肝硬化有一定价值。This experiment was carried out to make an exaluation on the non-invasive near-infrared detection of early hepatocirrhosis. The model of early hepatocirrhosis was established by injecting carbon tetrachloride in mice. Blood and oxygen content in liver tissue were detected with Runman System. The undulated forms of blood and oxygen variation were extracted and analyzed under the software MATLAB. Non-invasive near-infrared detection was found to react sensitively to the variation of the blood and oxygen content in the early hepatocirrhosis. The rhythm of the undulated forms of blood and oxygen in the early hepatocirrhosis was irregular. The main frequency peak of auto-power spectrum was found to move back to the rang 1.0-1.5 Hz and multi-peak was seen. These show that the non-invasive near-infrared detection is of some value in detecting early hepatoci-rrhosis.

关 键 词：近红外光 无创伤检测 早期肝硬化 实验研 MATLAB软件 肝硬化模型 氧含量 四氯化碳 肝脏组织 取血 

分 类 号：R575.2[医药卫生—消化系统]