容量超负荷对大鼠心肌肥大和血压的影响  

Effect of myocardio hypertrophy and blood pressure in rats with volume overload.

作　　者：许闽广[1] 高凌峰[1] 吉丽敏[1] 符史干[1] 

机构地区：[1]海南医学院生理教研室,海南海口571101

出　　处：《中国热带医学》2005年第7期1570-1571,共2页China Tropical Medicine

基　　金：国家自然科学基金资助课题(NO.30260032)

摘　　要：目的建立容量超负荷大鼠模型,分别测量全心室重、左心室重和右心室重与体重比值以及平均动脉压,观察容量超负荷条件下对大鼠心肌肥大和血压的影响,探讨容量超负荷引起心肌肥大和血压改变的机制。方法动静脉造瘘将连有注射器的9号静脉针头斜向上刺穿下腔静脉壁和动静脉联合壁,若刺穿时有突破感,证实针头已进入动脉管腔,用肝素生理盐水冲洗管腔后退出针头。结果手术组与假手术组及正常对照组比较心肌明显肥大;假手术组与正常对照组比较无显著性差异。手术组与假手术组与正常对照组比较收缩压、舒张压及平均动脉压均无显著性差异。结论容量超负荷可引起大鼠心肌肥大,引起肥大的机制可能与心肌细胞对容量超负荷的机械刺激信号产生应答反应,引起心肌细胞跨膜转导信号改变有关。Objective To measure the index of HW/BW, LVW/BM AND MAP in the rats with volum overload. And then study the meehanisim of myocardial hypertrophy. Methods Abdominal aorta- inferrer vena eava fistula was performed in the rats of volum overload group, the sham operation group and the control group. Both the index of HW/BW, LVW/BM and DP, SP were measured in each group after 60 days. Results Be competed with the control group and the sham operated group, the index of HW/ BW, LVW/BM of the volum overload group were significantly increased, There were no significant difference of the SP, DP and MAP among the three group. Conclusion These results suggest that volum overload can cause the hypertrophy of eardiomyocytes and it maybe induced by intraceUular signal transduction.

关 键 词：容量超负荷 心肌肥大 血压 

分 类 号：R364.3[医药卫生—病理学]