伊曲康唑增强义齿软衬材料抗菌性的研究  

Itraconazole enhances the antifungal ability of soft lining materials

作　　者：陶人川[1] 邓华颉[1] 黄光武[1] 

机构地区：[1]广西医科大学口腔医学院,广西南宁530021

出　　处：《临床口腔医学杂志》2005年第10期597-599,共3页Journal of Clinical Stomatology

基　　金：国家自然科学基金课题(30160087);广西青年科学基金项目(桂科青0144029)

摘　　要：目的:义齿佩带者常见口腔问题是念珠菌性义齿性口炎的发生,而义齿软衬材料的使用可增加义齿性口炎的易感性.本研究拟探讨在软衬材料中加入伊曲康唑后对抗菌性的影响.方法:选用德国梅卡硅橡胶室温固化软衬材料、COE SOFT软衬材料、日进软衬材料、自凝软衬垫等四种材料.抗真菌药物伊曲康唑分别按0%、3%、6%、9%(W/W)药物/试件的比例加入各材料中,分别制成标准试件后通过培养方法监测材料对白色念珠菌标准株的抗菌性以及时相关系.结果:在4种材料中,加入伊曲康唑试件对念珠菌的抑制性能较之同种未加入伊曲康唑者均有增加,具有统计学差异.不同材料中加入药物后,其抗菌性有一定的时间差异,但都在第6～8 d后抗菌性明显减低.696 W/W药物材料比例试件测试结果与9%者差异无统计学意义,但与0%或3%比较,抗菌效果增加.结论:无论何种材料,其表面念珠菌的生长抑制作用均与药物浓度有关,随着时间的推移,高浓度药物的材料对念珠菌生长抑制作用衰退较慢,但一定时间后,药物作用无明显差异;加入6%的浓度时即可达到有效抑菌作用.提示在软衬材料中加入伊曲康唑可作为暂时性软衬材料短期使用时预防义齿性口炎的积极措施.Objective：Soft lining materials play an important role in clinical removable prosthodontics, which relieves the pressure transmitted by denture on mucosa. However, there is an increased probability of yeast colonization on soft lining materials, which is a causative factor in denture stomatitis. This study aimed to investigate the function of addition of Itraeonazole into soft lining material for anti-candida adherence. Method： Four different types of soft lining materials were used in this study. Itraconazole was added into materials respectively by 3,6,9W/W drug/material ratio. Then making the mixed material into standard pieces for test the adherence of candida albican on the surface by culture, counting the cloning. Result：Among four kinds of materials, the pieces with itraconazole showed significantly stronger anti-fungal ability than the soft lining materials alone. The antifungal ability decreased within 6-8 days. No significantly difference observed between the 6 % w/w and 9% w/w for the same material, however, both showed higher antifungal ability than .samples with 3 % itraoanazole or with 0 % itraconazole. Conclusion： For any soft liner material, the inhibition ability to candida albican is associated with the concentration of i traconazole added; the re.asonable effect can be achieved by 6 % w/ w, and decreased by time. It suggests that itraconazole may be added into soft lining material to prevent denture stomatitis in short time purpose.

关 键 词：抗真菌药物 义齿软衬材料 伊曲康唑 白色念珠菌 

分 类 号：R781.54[医药卫生—口腔医学] R783.1[医药卫生—临床医学]