β-Adrenergic activation enhances NMDA-induced current in pyramidal cells of the basolateral nucleus of amygdala  

作　　者：LIU Xinqiu CAO Xiaohua LI Bao-ming 

机构地区：[1]Laboratory of Higher Brain Functions, Institute of Neurobiology, Institute of Brain Science, Fudan University, Shanghai 200433, China

出　　处：《Chinese Science Bulletin》2005年第17期1966-1968,共3页

基　　金：This work was supported by the Ministry of Sci-ence and Technology of China(Grant No.2006CB 500807);the National Natural Science Foundation of China(Grant Nos.30225023&30430240);the Shanghai Metropolitan Key Basic Research Program(Grant No.04DZ14005).

摘　　要：NMDA receptor (NMDA-R) in the amygdala complex is critical for both long-term potentiation (LTP) and formation of conditioned fear memory. It is reported that activation of β-adrenoceptors (β-AR) in the amygdala facili-tates LTP and enhances memory consolidation. The present study examined the regulatory effect of β-AR activation on NMDA-R mediated current in pyramidal cells of the baso-lateral nucleus of amygdala (BLA), using whole-cell re-cording technique. Bath application of the β-AR agonist iso-proterenol enhanced NMDA-induced current, and this fa-cilitatory effect was blocked by co-administered propranolol, a β-AR antagonist. The facilitatory effect of isoproterenol on NMDA-induced current could not be induced when the pro-tein kinase A (PKA) inhibitor Rp-cAMPs was added in elec-trode internal solution.The present results suggest that β-AR activation in the BLA could modulate NMDA-R activity di-rectly and positively, probably via PKA.NMDA receptor （NMDA-R） in the amygdala complex is critical for both long-term potentiation （LTP） and formation of conditioned fear memory. It is reported that activation of β-adrenoceptors （β-AR） in the amygdala facilitates LTP and enhances memory consolidation. The present study examined the regulatory effect of β-AR activation on NMDA-R mediated current in pyramidal cells of the basolateral nucleus of amygdala （BLA）, using whole-cell recording technique. Bath application of the β-AR agonist isoproterenol enhanced NMDA-induced current, and this facilitatory effect was blocked by co-administered propranolol, a β-AR antagonist. The facilitatory effect of isoproterenol on NMDA-induced current could not be induced when the protein kinase A （PKA） inhibitor Rp-cAMPs was added in electrode internal solution.The present results suggest that β-AR activation in the BLA could modulate NMDA-R activity directly and positively, probably via PKA.

关 键 词：β-肾上腺素 NMDA 受体 扁桃体 记忆体 

分 类 号：R977.11[医药卫生—药品]