原发性食管恶性黑色素瘤1例报道及文献复习  

Primary Malignant Melanoma of the Esophagus: a case report and review of literature

作　　者：马秀萍[1] 王岩[1] 李俊君[2] 

机构地区：[1]宁夏银川市第一人民医院,宁夏银川750001 [2]宁夏石嘴山市第一人民医院,宁夏石嘴山753200

出　　处：《宁夏医学杂志》2005年第10期684-685,共2页Ningxia Medical Journal

摘　　要：目的阐述食管原发性恶性黑色素瘤的临床病理特点及鉴别诊断要点。方法应用光镜观察及免疫组化染色,对1例食管原发性恶性黑色素瘤进行临床病理分析,同时复习相关文献。结果镜下可见上皮样、梭形、多边形的瘤细胞,呈片状、弥漫状浸润,并可见多量棕褐色色素颗粒。邻近的食管鳞状上皮轻-中度不典型增生,基底层黑色素细胞增生。免疫组化S-100阳性;HMB45阳性;Vimetin阳性;CK阴性;P53阳性;PCNA阳性;黑色素染色强阳性。结论食管恶性黑色素瘤是一种罕见的具有独特临床病理学特征的高度恶性肿瘤,预后差,应与食管的低分化癌及肉瘤鉴别,也要排除转移性恶性黑色素瘤。Objective To study the clinical pathologic characteristics and differential diagnosis of primary malignant melanoma of the esophagus （PMME）. Methods One case of PMME was sudiede by clinical data analysis. Results Under light Microscope epidermoid rumour cells, spindle tumour cells and polygonal tumour cells could be seen, pre.semeng picecs and hests. Also a great deal of brown heoplasma. Should be observed son section of adjacem esophagus squamous epithelium is evident atypical, and melanocytes of basal layer are hyperplastic. For immunphis to chemical staining S - 100 positive, HMB45, vimetin, P53 and PCNA are positive. Ck is negative. Conclusion PMME is a kind of infreqnent ated from poorly differentiated carcinoma and .vtrcorna of obsophagus. Also ambulant malignant melanoma should be excluded.

关 键 词：食管肿瘤 恶性黑色素瘤 

分 类 号：R735.1[医药卫生—肿瘤]