后程加速超分割三维适形放射治疗食管癌临床分析  

Analysis of the late course accelerated and hyperfrationated three dimensional conformal radiotherapy(3DCRT)for esophageal carcinoma

作　　者：陈国忠[1] 陈景林[1] 

机构地区：[1]福建医科大学附属第二医院放射治疗科,362000

出　　处：《福建医药杂志》2005年第5期1-3,共3页Fujian Medical Journal

摘　　要：目的回顾性分析后程加速超分割三维适形放射治疗(3 DCRT)食管癌的疗效.方法对80例胸段食管癌随机分为三维适形放疗组(观察组)40例和常规放疗组(对照组)40例.观察组先常规分割照射40Gy后改为后程加速超分割适形放疗,每次1.5 Gy,2次/日,间隔6小时.全程剂量67～72 Gy/38～41次,40～45d.同期常规放疗的40例为对照组,采用3野照射(前1后2),每次2 Gy,剂量65～70 Gy/33～35次,45～50 d.观察两组照射野大小差异、近期疗效及放疗不良反应.结果观察组照射野的个数及设野的平均长度和宽度大于对照组(P＜0.01).1、2级反应率高于对照组(P＜0.05),1年生存率及急性放射反应与对照组无显著性差异(P＞0.05).结论3 DCRT后程加速超分割三维适形放疗食管癌在保证临床靶区(CTV)受到高剂量照射的同时,其与PTV适形度好,近期疗效较好,且不增加放疗副反应.Objective To evaluate the value of late course accelerated and hyperfractionation three dimensional conformal radiotherapy （3DCRT） for esophageal carcinoma, compared with conventional fractionation radiotherapy （CFR）. Methods From July 2001 to August 2003, 80 patients with esophageal carcinoma were randomized into 3DCRT group and CFR group. After received Dr 40 Gy by CFR, 40 patients of 3DCRT group contionued to receive DT 30 Gy at 1.5 Gy twice daily with a minimum interfraction interval of seven hours by 3DCRT. The total dose varied up to 67-72Gy/38-41F/40-45d. Fourty cases of CFR group received DT 65-70 Gy/33-35 F/45-50 d, at two Gy once daily, five days per week by a three-port technique （one anterior and two posterior oblique fields）. Results Length and width of the radiation field of 3DCRT group were bigger than CFR group （P〈0.01）. one and two Grade response rate of 3DCRT group was higher than CFR group, 1-year survival rate and the acute radiation responses were not relevant （P 〉 0.05）. Conclusions Not only ensure clinical target volume （CTV） is made to be received high dose radiation by the late course accelerated and hyperfractionation 3DCRT for esophageal carcinoma, but also planning target volume （PTV） is made to be conformal. The short-term effects are well without increasing any untoward radioreactions.

关 键 词：食管肿瘤 放射疗法 三维适形放射疗法 超分割放射疗法 

分 类 号：R735.1[医药卫生—肿瘤]