双歧杆菌微囊肠溶胶囊的制备  

Preparation of capsule containing Bifidobacterium Microcapsules

作　　者：韩庆惠 李连会[1] 符岳中 吴世福[3] 

机构地区：[1]上海新药研究开发中心,上海201203 [2]上海中药创新中心,上海201203 [3]上海师范大学,上海200234

出　　处：《现代食品科技》2005年第4期51-53,共3页Modern Food Science and Technology

摘　　要：目的:制备全封闭的双歧杆菌活菌微囊胶囊。方法:采用胶囊肠溶包衣新技术和微囊化技术,将不同的高分子材料用于制备全封闭的双歧杆菌活菌微囊胶囊。结果:微囊和微囊胶囊在模拟人工胃液(pH1.5～2.0)中处理4h,活菌数分别保持在27.6%和84.4%以上,而在人工肠液中处理30min,微囊全部溶出释放出活性菌,释放率达90%以上。微囊胶囊在37℃下保存3个月(相当于常温下1年以上),其中的活菌数仍大于109个·g-1。结论:制备的微囊对活性菌有保护作用,有效地提高了活性菌体的耐酸性能,微囊中的菌体仍保持较高的活性且能在微囊中继续增殖。Objective： to prepare capsule containing bifidobacterium microcapsules. Methods： The target capsules were prepared with different high polymers using enteric coating and microencapsulation technologies. Results： After treated with artificial gastric solution （pH1.5-2.0） for 4h, the viable bifidobacterium in microcapsules were still more than 27.6%, in the completely closed capsules they are still more than 84.4%.After treated with artificial enteric solution （pH6.8） for 30 min, the microcapsules have completely disintegrated and the viable organism released into solution were still more than 90% of the label amount. After storing capsules at 37℃ for 3 months, the amount of viable bifidobacterium were still〉1.0×10^9·g^-1. Conclusion： Microencapsulation has protective effect on viable bifidobacterium and effectively increases the results acid-tolerance ability of bifidobacterium. In microcapsules, bifidobacterium keeps a higher competence and can continuously proliferate.

关 键 词：微囊化 双歧杆菌 肠溶包衣技术 微囊化技术 肠溶胶囊 双歧杆菌 制备 高分子材料 活菌数 活性菌 人工胃液 人工肠液 

分 类 号：TQ460.6[化学工程—制药化工]