口腔颌面部上皮样血管瘤临床病理研究  

Clinicopathological Analysis of Epithelioid Hemangioma in Oral and Maxillofacial Region.

作　　者：孙志军[1] 张露[2] 张文峰[1] 刘冰[1] 陈新明[3] 赵怡芳[1] 

机构地区：[1]武汉大学口腔医学院口腔颌面外科,湖北武汉430079 [2]口腔生物工程教育部重点实验室 [3]武汉大学口腔医学院病理科

出　　处：《口腔医学研究》2005年第5期549-551,共3页Journal of Oral Science Research

摘　　要：目的:探讨口腔颌面部上皮样血管瘤的临床、病理学特征及生物学行为。方法:回顾性分析7例口腔颌面部上皮样血管瘤的临床资料,常规HE染色及弹力纤维染色,光镜观察,全部标本行免疫组织化学染色分析其病理学特点。结果:7例患者中,男性4例女性3例。肿瘤分别位于舌、唇部、鼻根及腭部。5例表现为表浅单发性肿块,3例有创伤史。组织学表现为毛细血管和小血管增生,内皮细胞呈上皮样或组织细胞样改变;病变内有慢性炎性细胞浸润。免疫组织化学检测,全部标本V im entin、FⅧRAg、UEA-1、CD34及α-SMA阳性,S-100蛋白、广谱CK及GLUT-1染色阴性。手术治疗后2例复发,无转移。结论:上皮样血管瘤是一种良性血管病变,可能与局部创伤有关。Objective： To investigate the clinicopathological characteristics and biologic behavior of epithelioid hemangioma in oral and maxillofacial regions. Methods： The clinical features and pathological findings of 7 epithelioid hemangioma cases were reviewed, and all the sections were examined by immunohistochemistry. Results; There were 4 males and 3 females ranged from 8 to 65 years （ mean 36 years）. Primary lesions site included the tongue （ n = 3 ） , lip （ n = 2）, nasal root（n = 1 ）, and palate （n = 1 ）. Five lesions presented as a solitary mass, and 3 patients had history of trauma. Histopathlogically, well formed but often immature vessels lined by plump epitholid endothelial cells with prominent inflammatory components were observed. Immunohistochemical staining revealed that tumor cells were positive for Vimentin, FⅧ Rag, UEA - 1, CD34 andα -SMA and negative to S - 100 protein, Pan -CK and GLUT - 1. Two cases recurred after surgical excision while none of them metastasized. Conclusion： Epithelioid hemangioma is a benign vascular anomalies, and has close relationship with local trauma.

关 键 词：上皮样血管瘤 血管肿瘤 病理学 免疫组织化学 

分 类 号：R739.8[医药卫生—肿瘤]