直肠癌腔内超声与微血管密度对比研究  

Contrast study on rectal cancer vascularity with transrectal Doppler ultrasonography and pathologic microvessel density

作　　者：叶卫华[1] 于跃明[1] 赵玉珍[1] 纪晓惠[1] 杨漪[1] 薛逊[1] 

机构地区：[1]河北医科大学第四医院超声科,石家庄050011

出　　处：《中华超声影像学杂志》2005年第10期758-760,共3页Chinese Journal of Ultrasonography

基　　金：河北省卫生厅科技攻关课题(03010)

摘　　要：目的探讨直肠癌动脉血流阻力指数(RI)与微血管密度(microvessel density,MVD)的相关性及其与TNM分期的关系。方法63例直肠癌患者术前行经直肠多普勒超声检查,测量瘤内RI,术后确定肿瘤TNM分期,以抗CD105单克隆抗体行免疫组织化学染色,计数MVD,分析RI与MVD的相关性及其与TNM分期的关系。结果RI与MVD呈负相关(rs=-0.4225,P<0.01);各TNM分期RI比较Ⅰ期与Ⅲ、Ⅳ期,Ⅱ期与Ⅲ、Ⅳ期之间差异有显著性意义(P<0.05);各TNM分期之间MVD比较差异有显著性意义(P<0.05)。结论直肠癌RI可于术前反映肿瘤组织内血管生成活性,低RI反映了癌组织内高MVD状态。RI可间接反映直肠癌的病程进展,有一定的临床意义。Objective To explore whether resistance index （RI） correlates with the microvessel density（MVD） in rectal cancers and TNM stage. Methods Sixty-three cases with rectal cancer were examined preoperatively by transrectal Doppler ultrasonography, RI of arteries in rectal cancers were detected. After operation all cases were staged according to TNM standard. All the slices of tumor tissue specimens were stained immunohistochemistry with anti-CD105 monoclonal antibody and MVD were calculated separately. Relationships between RI, MVD and stages of the disease were analysed. Results There was negative correlation between RI and MVD（ rs = -0.4225, P 〈0. 01）. There were statistical differences of RI in different groups（TNM stage Ⅰ and Ⅲ , Ⅰ and Ⅳ, Ⅱ and Ⅲ , Ⅱ and Ⅳ） （ P 〈0. 05）. There were significant differences of MVD in all TNM stages（ P 〈0. 05）. Conclusions RI of arteries in rectal cancers can evaluate the growing activity in tumor vessels. Lower RI showed higher MVD in rectal cancers. RI can reflect the development of rectal cancers indirectly and possesses a clinical meaning.

关 键 词：腔内超声检查 直肠肿瘤 肿瘤分期 直肠癌患者 微血管密度 阻力指数(RI) 腔内超声 TNM分期 免疫组织化学染色 多普勒超声检查 血管生成活性 单克隆抗体 

分 类 号：R735.37[医药卫生—肿瘤] R737.9[医药卫生—临床医学]