毫米波并放疗治疗浅表转移瘤的研究  

Millimeter wave combined with radiotherapy for treatment of superficial metastatic tumors

作　　者：张峰[1] 孙仲藩[1] 彭俊云[1] 潘琳[1] 李茜[1] 顾广源[1] 

机构地区：[1]空军总医院放射治疗科,北京中日友好医院细胞生物室,北京航天工业总公司二院四部

出　　处：《中华理疗杂志》1996年第1期3-5,共3页Chinese Journal of Physical Therapy

摘　　要：采用频率３６．５ＧＨｚ、输出功率１２０ｍＷ、功率密度７ｍＷ／ｃｍ２毫米波配合放疗治疗浅表转移瘤，癌细胞ＤＮＡ荧光强度测定，以任意单位ＡＵ表示，实验组平均为１２００．７０±７０．５０，对照组平均为１５０５．２７±７１．４８（ｔ＝３．００４，Ｐ＜０．０５）。癌细胞ＤＮＡ吸收光定量分析，以任意单位ＡＵ表示，实验组总吸收平均为５８．７１±３．１０，总面积平均为３０９．８４±１４．５０，对照组分别为７３．８７±４．９６和３５０．３５±６．６９（ｔ＝２．５８９，Ｐ＜０．０５；ｔ＝２．５３４，Ｐ＜０．０５）。临床观察结果：毫米波辐射并放疗治疗浅表转移瘤ＤＴ４０Ｇｙ、７０Ｇｙ两次评定疗效，ＣＲ＋ＰＲ综合组均为１００％，单纯放疗组４０Ｇｙ为２５．０％、７０Ｇｙ为８４．６％，两组疗效对比差异有显著性（ＤＴ４０Ｇｙ比较Ｘ２＝３６１．１，Ｐ＜０．００５；ＤＴ７０Ｇｙ比较Ｘ２＝２２９．６，Ｐ＜０．００５）。研究结果表明，毫米波辐射对癌细胞有一定程度的抑制和杀伤作用，综合治疗组疗效优于单纯放疗组。毫米波辐射并放疗治疗浅表转移瘤，不仅有放疗增效作用，而且对正常组织有保护和修复作用。in this paper,the superficial metastatic tumors including the animals and patients were treated with millimeter (MM) wave(36. 5GHz, 12mW, 7mW/cm2) and radiotherapy to observe their effects. Using the fluorescence intensity measurement (which was indicated by AU), it was shown that the DNA fluorescence intensity of cancer cells in experimental group was 1200. 70±70. 50,and that of control group was 1505.27±71. 48 averagely. There was a difference(P<0. 05). From the quantitative analysis of light absorption in cancer cell DNA, the all absorption value was averagely 58.71± 3. 10 and the value of-total-area was 309. 84±14. 50. While the control group was 73. 87± 4. 96 and 350. 35±6. 69 respectively(P<0. 05). On the clinical study,the patients treated by synthetic therapy all received CR and PR, those by single radiotherapy were only 25. 0% (CR) and 84. 6% (PR). This study indicated that the MM wave irradiation on the cancer cells presented a cancerocidal effect. When the MM wave is combined with the radiotherapy, they can enhance the therapeutic effects and protect the normal tissues or repair them.

关 键 词：毫米波 放射治疗 转移瘤 

分 类 号：R730.1[医药卫生—肿瘤]