血铅、镉等6种元素对幼儿行为问题影响的横断面研究  

A cross-sectional study of the effects of blood lead and cadmium etc six elements on infant behavior problems

作　　者：朱中平[1] 沈彤[1] 杨永坚[1] 俞翠莲[2] 邹武庆[2] 刘俊玲 姜玉屏 朱启星[1] 

机构地区：[1]安徽医科大学公共卫生学院,合肥230032 [2]池州市疾病预防控制中心,池州247100 [3]池州市贵池区妇幼保健所,池州247100

出　　处：《安徽医科大学学报》2005年第6期560-563,共4页Acta Universitatis Medicinalis Anhui

基　　金：安徽省高校省学术带头人科研基金资助(编号:2002HBL10);安徽省计划生育科研项目(200204);安徽省卫生厅科研项目(2002B090)

摘　　要：目的研究血铅、镉、钙、锌、铜、铁6元素对幼儿行为问题的影响及其关联程度。方法采用分层抽样方法,抽取安徽省池州市某区2～3岁幼儿共206名。对幼儿进行了体格检查、问卷调查(家长用);采用2～3岁Achenbach幼儿行为量表(CBCL)对幼儿进行了行为问题测试;采集指血206份,运用PEAA800原子吸收光谱仪进行了血铅、镉、钙、锌、铜、铁六种元素检测。结果①幼儿行为问题检出率为12.6%。②多因素逐步回归分析显示幼儿血镉水平与攻击行为得分存在正相关(β=0.178,P<0.05);血钙水平与忧郁行为得分存在负相关(β=-0.173,P<0.05)③幼儿血铅水平与睡眠问题(β=0.151)、破坏(β=0.156)、外向性行为(β=0.179)、总分(β=0.156)得分间均存在正相关(P值均<0.05),且高血铅组与正常血铅组幼儿在攻击、破坏行为、外向性等6个方面差异有统计学意义(P值<0.05)。结论研究认为血铅、镉、钙对幼儿行为问题有一定影响。Objective To study the effect of Lead, Cadmium, Calcium, zinc, copper and iron on infant behavior problems. Methods We selected 206 infants（2 -3 years old ） in Chizhou city, Anhui province by stratified sampiing. We tested their behavior problems with Achenbach child behavior checklist（CBCL） and investigated them with our questionnaire. Meanwhile, we assayed the levels of the six metal elements in blood of infants, with the instrument of PE-AA800 Atomic Absorption Spectrophotometer. Results ① In the 206 infants, the prevatence of abnormal behavior problems is 12.6%. ② There was positive association between the content of blood Cadmium and the score of attack in infants （ β = 0. 178, P 〈 0. 05 ） , while the score of depression was negatively correlated with infants blood Calcium（ β = -0. 173 ,P 〈0. 05）. ③The multiple stepwise regression analysis showed that the score of sleep, destructivity, extraversion, total score were positively correlated with infant BLL, respectively. And the scores of six factors （ attack, destructivity, extraversion et al） in the HBL（ high blood level） group were much higher than those in NBL（ nomal blood level） （ P 〈 0. 05 ）. Conclusion Our study suggests that infant behavior problems are associated with the contents of their blood lead, cadmium, calcium.

关 键 词：铅/血液 镉/血液 钙/血液 儿童行为障碍 横断面研究 

分 类 号：R749.94[医药卫生—神经病学与精神病学]