肿瘤相关性低磷抗D骨软化症的外科干预治疗  

Surgical treatment of tumor-induced osteomalacia

作　　者：金今[1] 邱贵兴[1] 陈宾[1] 于斌[1] 高增鑫[1] 刘正[1] 李其一[1] 

机构地区：[1]中国医学科学院中国协和医科大学北京协和医院,100730

出　　处：《中国骨质疏松杂志》2005年第3期346-348,共3页Chinese Journal of Osteoporosis

摘　　要：目的观察分析采用外科手术方法治疗肿瘤相关性低磷抗D骨软化症的早期疗效及此类肿瘤的外科学特点。方法从2004年2月至2005年3月,对7例诊断为肿瘤相关性低磷抗D骨软化症的患者进行手术治疗,完整切除软组织肿瘤5例,骨肿瘤2例。术后平均随访4个月(2周～12月)。结果6例患者术后临床症状明显改善,血磷恢复正常,1例未见明显改善。结论肿瘤低磷抗D骨软化症是一种罕见病例,5例软组织肿瘤临床症状少,常规体检不易发现;2例骨肿瘤在X线片上仅表现为骨密度增高区,无明显溶骨及破坏,易被误诊。一经确诊,手术治疗效果良好。Objective To observe and analyze the early therapeutic effects of treating the tumor-induced vitamin- D resistant hypo-phosphate osteomalacia by surgical intervention and surgical characters of this kind of tumor. Methods Seven patients with the diagnosis of tumor-induced vitamin-D resistant hypo-phosphate osteomalacia received complete resection operations of tumors from February 2004 to March 2005, with 5 cases of soft connective tissue tumor and 2 of bone tumor. The follow-up period ranged from 2 weeks to 12 months （mean,4 months）. Results Six patients improved their symptoms dramatically after operation, with serum phosphate levels restore to normal. One patient has no significant mprovement. Conclusions Tumor-induced vitamin-D resistant hypo- phosphate osteomalacia is a kind of rare disease. Five patients with soft connective tissue tumor have few symptoms, hard to be found by physical examination. X-ray films of two patients with bone tumor show increased density of bone, without obvious osteolysis and bone destructions, therefore it is easy to misdiagnose. Once confirmed, Surgical treatment is necessary,and can achieve a good effect.

关 键 词：肿瘤相关性骨软化症 手术 肿瘤相关性 外科干预治疗 骨软化症 抗D 低磷 外科手术方法 软组织肿瘤 临床症状 骨密度增高 

分 类 号：R730.53[医药卫生—肿瘤] R655.3[医药卫生—临床医学]