膦甲酸钠治疗活动性肝硬变8例  

Phosphine Formicacid Sodium treat Activity8cases of Cirrhosis

作　　者：杜爱梅[1] 

机构地区：[1]大同市第四人民医院,037008

出　　处：《大同医学专科学校学报》2005年第3期4-4,13,共2页Journal of Datong Medical College

摘　　要：目的:探讨应用膦甲酸钠(可耐)治疗活动性肝硬变的疗效。方法:对8例病人采用膦甲酸钠(可耐)注射液治疗。观察临床症状、体征、血常规、肝功能、总胆红素(TB)、丙氨酸转氨酶(ALT)、天门冬氨酸转氨酶(AST)、白蛋白(ALB),血清HBV标志及膦甲酸钠的不良反应。结果:临床症状改善明显,肝功能治疗前后有显著改善,其它指标显著好转。均未发生严重肾损害、明显电解质紊乱等不良反应,耐受性良好。结论:膦甲酸钠对乙型肝炎的DNA聚合酶有快速直接的抑制作用,用于治疗活动性肝硬变有较好疗效。Objective：Probe into and use the curative effect of treating the activity cirrhosis of phosphine formic acid sodium. Method：Adopt the injectio of phosphine formic acid sodium to treat to 8 patients. Observe clinical symptom, body to solicit, blood routine, liver function, total bilirubin （TB）, third ammonia acid is transfered to the ammonia enzyme（ALT）, lucid asparagus ammonia and acid are transfered to the ammonia enzyme （AST） ,a lbum in （ALB）, the serum HBV sign, the bad reaction of the phosphine formic acid .sodium. Result： The clinical symptom is improved obviou sly, liver function is compared and improved notably before and after treated, other indexes take a favorable turn notably. The serious kidney has not happened and damage, the bad reaction such as being disorderly of obvious electrolyte, tolerance is good. Conclusion： The phosphine formic acid sodium has fast and direct inhibition to get enzymes together on DNA of hte hepatitis B. Used for treating the activity cirrhosis and having better curative effect.

关 键 词：膦甲酸钠 活动性肝硬变 乙型肝炎 活动性肝硬变 膦甲酸钠 治疗前后 天门冬氨酸转氨酶 胆红素(TB) 血清HBV标志 丙氨酸转氨酶 DNA聚合酶 临床症状 

分 类 号：R575.2[医药卫生—消化系统] R512.62[医药卫生—内科学]