p16与nm23在膀胱癌中的表达及临床意义  

p16 and nm23 expression in bladder carcinoma

作　　者：杨宏梅[1] 郑美珍[1] 

机构地区：[1]辽宁省肿瘤医院内四科,沈阳110042

出　　处：《实用肿瘤学杂志》2005年第5期344-345,共2页Practical Oncology Journal

摘　　要：目的探讨p16和nm23在膀胱移行细胞癌中的表达及临床意义。方法采用免疫组化SP法观察69例膀胱癌石蜡标本中p16和nm23的表达情况。结果膀胱癌组织中p16和nm23的阳性表达率分别为40.57%和43.48%,阳性表达率随病理分级、临床分期升高而下降,复发肿瘤阳性表达率显著低于未复发病例。结论p16和nm23表达可能成为判断膀胱癌生物学行为的重要指标之一。Objective To investigate clinical significance and expression of p16 and nm23 in bladder transitional eeU carcinoma. Methods p16 and nm23 expression were detected in 69 specimens by SP of immu- nohistechemistry. Resets 40.57% of bladder carcinoma were positive in p16 expression, while 43.45% were positive in nm23 expression. Significant correlation was found between p16, nm23 positive expression and tumor grade and clinical stage, the lower the p16, nm23 positive expression is, the higher the tumor grade and clinical stage. In relapsing bladder carcinoma, the positive expression were lower. Conclusion p16 and nm23 expression may be a useful prognostic indicator and potentially useful for assessing tumor malignant extent.

关 键 词：膀胱癌 P16 NM23 NM23表达 膀胱癌组织 临床意义 P16 阳性表达率 膀胱移行细胞癌 癌生物学行为 表达情况 石蜡标本 

分 类 号：R737.14[医药卫生—肿瘤]