MMP-9/TIMP-1在葡萄胎中表达及与临床病理参数相关性  

The Expressions of Matrix Metalloproteinase-9(MMP-9) and Tissue Inhibitor of Metalloproteinase-1(TIMP-1) in Hydatidiform Moles and their Correlation with Clinicopathological Parameter

作　　者：步仰高[1] 张洪福[2] 胡勇 朱贝利[1] 

机构地区：[1]解放军105医院,安徽合肥230031 [2]安徽医科大学病理教研室,安徽合肥230032

出　　处：《中国肿瘤》2005年第11期763-766,共4页China Cancer

摘　　要：[目的]研究基质金属蛋白酶(MMP-9)及其组织抑制剂(TIMP-1)在葡萄胎滋养细胞中的表达及其与临床病理参数的相关性。[方法]应用链霉菌抗生物素蛋白—过氧化物酶免疫组织化学方法检测15例部分性葡萄胎、55例完全性葡萄胎滋养细胞中MMP-9、TIMP-1表达。[结果]葡萄胎患者MMP-9的表达与年龄和清宫次数有相关性(分别为rs=0.262,P=0.028;rs=0.390,P=0.001)。TIMP-1的表达与卵巢黄素化囊肿、清宫前血β-HCG值、血β-HCG转阴时间、妊娠呕吐、合并妊娠高血压综合征及清宫次数有相关性。[结论]MMP-9与葡萄胎患者的年龄和清宫次数有关,HCG可能影响葡萄胎TIMP-1的表达,MMPs/TIMPs比例的改变也可能是滋养细胞疾病发生妊娠高血压综合征的原因之一。[Purpose]To investingate the expression of matrix metalloproteinases（MMP-9）and tissue inhibitors of metalloproteinases（TLLMP-1）in hydatdiform mole and their correlation with clinicopathological parameters,[Methods]Immunohistochemical streptavidin-peroxidase（S-P）method was used to detect the expression of MMP-9,TIMP-1,in 15 cases with partial hydatidiform moles and 55 cases with complete hydatidiform mole.[Results]In hydatidiform mole,the expression of MMP-9 correlated with age and times of curettage（r=0.262,P=0.028;r=0.390,P=0.001）.The expression of TIMP-1 ovarian theca lutein cyst ,serum titers of β-human chorionic gonadotropin（β-HCG）before evacuation,duration of negative β-HCC,emesis.[Conclusions]The expression of MMP-9 correlates with age and times of curettage in hydatidiform mole,HCG may impact on the expression of TIMP-1.The change proportion of MMPs/TIMPs might be one of the genesis of pregnancy-induced hypertension syndrome in human gestational trophoblastic disease,

关 键 词：金属蛋白酶类 金属蛋白酶组织抑制因子 妊娠 滋养细胞疾病 免疫组织化学 

分 类 号：R737.33[医药卫生—肿瘤]