精神分裂症患者利培酮治疗前后认知功能的研究  

Effect of Risperidone in the Treatment of Schizophrenia on Cognitive Function.

作　　者：行养玲[1] 杨旭[1] 郭娟[1] 张丽[1] 张凯[1] 

机构地区：[1]中国.西安市精神卫生中心,710061

出　　处：《中国健康心理学杂志》2005年第6期434-435,共2页China Journal of Health Psychology

摘　　要：目的研究精神分裂症患者利培酮治疗前后认知功能是否有所改善.方法研究对象符合CCMD-3精神分裂症诊断标准,病程≤2年,首发住院,实际完成研究50例.采用中国修订的韦氏成人智力量表(WAIS-RC),韦氏成人记忆量表(WMS-RC),于治疗开始时和第8周末分别进行两次评定.利培酮的每日剂量为2～8mg.结果大多数分测验项目和言语智商、操作智商、智商总分、记忆商数,在治疗前后都有显著性差异.结论利培酮对精神分裂症患者的认知功能障碍有改善作用.Objective To study effect of risperidone in treatment of schizophrenia on cognitive function. Methods 50 patients met CCMD- 3 diagnostic criteria of Schizophrenia, course of disease ≤ two years, all case is first episode inpatients, we adopt WAIS- RC, WMS-RC test for all patients, test carried on treatment before and eighth weeks. Every day dose of Risperidoue is 2-8mg. Results Most test of FIQ, VIQ, PIQ, MQ were significantly worse （P〈0.05）. Conclusion Risperidone can improve schizophrenia＇s cognitive function.

关 键 词：利培酮 精神分裂症 认知功能 韦氏成人智力量表 韦氏成人记忆量表 精神分裂症患者 认知功能障碍 治疗前后 利培酮 韦氏成人智力量表 CCMD-3 言语智商 显著性差异 研究对象 

分 类 号：R749.3[医药卫生—神经病学与精神病学] R749.16[医药卫生—临床医学]