CT引导下经皮穿刺肝内乙醇注射的实验研究  

Experimental research of percutaneous intrahepatic ethanol injection under CT guidance

作　　者：康德强[1] 田建明[1] 相成[1] 张峰[1] 左长京[1] 臧婷臻[1] 史丽静[1] 袁小东[1] 田媛[1] 李士建[1] 

机构地区：[1]第二军医大学长海医院放射科,上海200433

出　　处：《介入放射学杂志》2005年第5期526-529,共4页Journal of Interventional Radiology

基　　金：国家自然科学基金(30270419)

摘　　要：目的探讨在CT引导下经皮穿刺肝内不同剂量、不同浓度与不同温度乙醇注射对兔肝脏损伤的情况。方法取健康新西兰兔54只,以随机分组进行肝内乙醇注射,各组分别于术后次日、1周、2周取材病理检查,并于术前及术后1、3、7、10和14d耳缘取血生化检查与影像学观察。结果乙醇浓度与注射总量对兔肝内凝固灶大小均有影响,两者之间存在交互作用。病理光镜检查肝内灶呈典型凝固性坏死。生化检查肝功能损害呈一过性。结论该方法对肝脏损伤小,安全、可行。Objective To study percutaneous ethanol injection caused liver injures on rabbits with different doses, concentrations and temperatures. Methods The experiment was carried out in 54 New Zealand rabbits under randomized dividing groups with the purpose of observing the microscopic pathologic changes after 1 day, 1 week, 2 weeks of ethanol injection and the blood sampling biochemical with imaging changes, 1, 3, 7, 10, 14 days before and after injection. Results Both total ethanol dose and concentration can cause different size of necrosis on rabbits liver tissue with the interactions between them. Pathologic changes in rabbits liver appeared to be typical coagulative necrosis. The injuries causes by ethanol injection were transient and repairable after a short period. Conclusions Percutaneous ethanol injection causes mild injures to the liver. The method is safe and practicable.

关 键 词：乙醇 穿刺术 CT引导 动物 实验 CT引导下 乙醇注射 经皮穿刺 肝内 实验研 血生化检查 凝固性坏死 新西兰兔 肝脏损伤 

分 类 号：R735.7[医药卫生—肿瘤]