微血管密度在脑星形细胞瘤中的检测及意义  

Experimental study on microvessel density in brain astrocytoma and its significance

作　　者：平金良[1] 章步文[1] 

机构地区：[1]浙江省湖州市中心医院病理科,313000

出　　处：《肿瘤研究与临床》2005年第5期327-328,共2页Cancer Research and Clinic

摘　　要：目的观察脑星形细胞瘤组织中微血管密度(MVD),分析其与临床病理特征及与预后的关系。方法采用免疫组织化学方法,检测52例脑星形细胞瘤组织中微血管生成情况。结果脑星形细胞瘤组织中MVD为71.8±27.8,高于正常脑组织25.8±6.2,差异有显著性(P<0.01);高级别脑星形细胞瘤中(Ⅲ,Ⅳ级)MVD为81.7±26.9,显著高于低级别(Ⅰ,Ⅱ级)52.8±18.4,差异有统计学意义(P<0.01);术后复发死亡患者MVD高于未复发死亡患者(P<0.01)。结论MVD反映瘤组织内血管生成状态,与肿瘤的组织级别密切相关,可作为脑星形细胞瘤预后指标。Objective To investigate the relationship between microvessel density （MVD）, clinicophathological characteristics and the prognosis in brain astrocytoma. Methods To determine the generation level of microvessel in 52 cases brain astrocytoma with immunohistochemistry. Results MVD in brain astrocytoma tissues was higher （71.8±27.8） than that in normal brain tissues （25.8±6.2） （P 〈0.01）. Brain astrocytoma with high grade （Ⅲ-Ⅳ） had higher MVD （81,7±26.9） than that with low grade （52.8±18.4） （P 〈 0.01）. MVD in patients with death group was higher than non-death group （P 〈0.01）. Conclusions MVD reflects the state of angiogenesis in tumor, it is closely related with its tissular grade and MVD may be regarded as a prognostic factor in brain astrocytoma.

关 键 词：脑肿瘤 星形细胞瘤 微血管密度 血管形成 

分 类 号：R739.4[医药卫生—肿瘤]