重组链激酶动脉内灌注治疗大鼠脑血栓  

Thrombolytic therapy with recombinant streptokinase (r-SK) in embolic rat stroke model

作　　者：彭鲁英[1] 任军[1] 钟凯声[2] 吕敏[2] 黄阳滨[1] 蔡旭[1] 宋后燕[1] 

机构地区：[1]上海医科大学分子遗传学研究室,200032 [2]中国科学院上海生理研究所

出　　处：《中华实验外科杂志》1996年第2期91-92,共2页Chinese Journal of Experimental Surgery

摘　　要：用动脉型血栓将28只雄性Wistar大鼠造成脑栓塞模型,通过颈动脉局部灌注治疗,观察重组链激酶(r-SK)对脑血栓的溶栓作用。结果表明,动物栓塞后30分钟,平均局部脑血流(rCBF)下降了64%,血压、体温和血气值等生命指数维持恒定。经r-SK加人纤溶酶原灌注治疗后,rCBF重灌注显著增加,而对照组动物rCBF未见恢复。说明r-SK具有明显的溶栓治疗作用。提示发病后尽早进行溶栓治疗对恢复梗塞区脑血流十分重要。In order to study the thrombolytic effects of streptokinase (r-SK), 28 male Wistar rats was embolised in the carotid artery. Regional cerebral blood flow (rCBF) was reduced by 64% with life indexes unchanged 30 min after embolization. After perfusion with r-SK and human plasminogen r-SK reperfusion revealed a significant increase (P<0.01) in treatment group as compared with control group. R-SK was proved to possess obvious thrombolytic effect. The results also suggested that early thrombolytic therapy was very important for achieving recovery of cerebral blood flow at related region.

关 键 词：重组链激酶 大鼠 脑血栓 溶栓疗法 动脉内灌注 

分 类 号：R743.330.5[医药卫生—神经病学与精神病学]