多原发性肺癌与支气管肺泡上皮异型增生关系的研究  

Correlation of multiple primary lung cancer with bronchial and alveolar epithelial dysplasia

作　　者：王国凤[1] 来茂德[2] 陈培辉[1] 

机构地区：[1]浙江大学医学院附属第二医院病理科,浙江杭州310009 [2]浙江大学医学院病理学与病理生理学教研室,浙江杭州310031

出　　处：《浙江大学学报（医学版）》2005年第5期427-431,共5页Journal of Zhejiang University(Medical Sciences)

摘　　要：目的:探讨多原发性肺癌与支气管上皮异型增生及肺泡上皮不典型腺瘤性增生之间的关系。方法:对114个手术切除的原发性肺癌标本进行病理组织学检查,观察多原发性肺癌的存在,支气管上皮异型增生,以及肺泡上皮不典型腺瘤性增生的数目,分析多原发性肺癌与支气管上皮异型增生及其程度,肺泡上皮不典型腺瘤性增生之间的关系。结果:在114个原发性肺癌标本中发现多原发性肺癌13例,其中6例2个原发性肺癌为支气管肺癌,7例2个原发性肺癌为支气管肺癌和肺泡细胞癌。经Spearman相关分析,多原发性肺癌与支气管上皮异型增生级别呈正相关(r=0.238,P<0.05)。结论:支气管及肺泡上皮细胞可同时或先后发生原发性肺癌;有广泛支气管上皮高级别异型增生者肺多原发性癌发生概率增高。Objective： To investigate the correlation of multiple primary lung cancer with bronchial epithelial dysplasia and atypical adenomatous hyperplasia of bronchiolo-alveolar epithelium. Methods： Careful pathological examinations were performed on 114 surgical specimens of primary lung carcinoma. The correlation of multiple primary lung cancer with bronchial epithelial dysplasia and atypical adenomatous hyperplasia of bronchiolo-alveolar epithelium was analyzed. Results：Of 114 cases of primary lung cancer, 13 cases of multiple primary lung cancer （11. 4%） was identified, which consisted of 6 cases containing two primary bronchogenic carcinoma and 7 containing one bronchogenic carcinoma and one bronchiolo-alveolar carcinoma. The rate of multiple primary lung cancers was significantly higher in individuals with high grade bronchial epithelial dysplasia than in those with low grade dysplasia （r= 0. 238,P〈0.05 ）. Conclusion： Bronchial and alveolar epithelial cells may develop malignancy synchronously or metachronously. The probability of developing multiple primary lung cancer will increase in the lungs with extensive and severe bronchial epithelial dysplasia.

关 键 词：肺肿瘤/病理学 肿瘤 多原发性 腺瘤/病理学 增生 肺泡/病理学 支气管/病理学 腺癌 细支气管肺泡/病理学 

分 类 号：R734.2[医药卫生—肿瘤]