血卟啉衍生物配合放射治疗鼻咽癌患者三项免疫功能的检测  

Influence of HPD on immunological functions in patients with nasopharyngeal carcinoma treated by radiotherapy

作　　者：夏云飞[1] 张恩罴[1] 胡永红[1] 

机构地区：[1]中山医科大学肿瘤防治中心放疗科,广州510060

出　　处：《中华耳鼻咽喉科杂志》1996年第3期168-170,共3页Chinese Journal of Otorhinolaryngology

摘　　要：观察在放射治疗鼻咽癌时血卟啉衍生物（hematoporphyrinderivative，HPD）对患者免疫功能的影响，选择病理确诊的初诊鼻咽癌78例，分成单纯放疗组和血卟啉衍生物（HPD）＋放疗组，各39例，采用自身配对方法，分别测定各组放疗前、后免疫功能。结果为：①HPD＋放疗组放疗前后免疫功能无明显变化；②单纯放疗组放疗后较放疗前免疫功能明显下降，包括OKT3、OKT4、OKT4／OKT8和淋巴细胞转化率均具有统计学意义（P＜0．01和P＜0．05）。上述结果提示HPD配合放射治疗鼻咽癌对免疫功能具有一定的保护作用。Seventy-eight patients with nasopharyngeal carcinoma were equally divided into two groups: 39 patients were treated by HPD plus radiation and 39 patients by radiation alone. Immuno logical functions were evaluated in each patient before and after radiation. The results showed that (1 ) in patients treated by HPD and radiation, no statistical difference was observed on immunological functions be fore and after treatment; (2) in patients treatd by radiation alone, the immunological functions, including OKT3, OKT4, OKT4/OKT8 ratio and lymphocyte transformation, were signifi-cantly decreased after treatment. These findings indicate that the immunological functions in patients with nasopharyngeal carcinoma could be protected by HPD during radiotherapy.

关 键 词：鼻咽肿瘤 卟啉 放射疗法 免疫功能 

分 类 号：R739.630.5[医药卫生—肿瘤]