氯喹对大鼠精子发生和形成的影响  

EFFECT OF CLOROQUINE ON SPERMATOGENESIS AND SPERMIOGENESIS IN RAT

作　　者：盛毅[1] 张蕙心[1] 汤雪明[1] 王一飞[1] 

机构地区：[1]上海第二医科大学组织学胚脂学教研室,上海第二医科大学细胞生物学实验室

出　　处：《解剖学报》1996年第2期184-188,共5页Acta Anatomica Sinica

摘　　要：以不同剂量的氯喹灌胃大鼠，发现曲细精管腔中有较多的不成熟精子细胞脱落，并出现巨核细胞，异常长形精子细胞等退行性变化。各级生精细胞溶酶体体积增大，电子密度降低。精子细胞尾部胞质中溶酶体肿胀早于顶体。精子细胞尾部发育异常多见。氯喹可能通过提高溶酶体内的ｐＨ，抑制细胞的代谢和细胞发育，溶酶体破裂引起细胞自溶；另外，氯喹抑制精子细胞溶酶体的功能，是导致精子细胞尾发育异常的一个重要原因。Cloroquine was given to rat by gastric gavage with different doses.Degenerative changes of the seminiferous epithelial cells are evident following drug treatment.The volume of lysosomes in spermatogenic cells enlarges,with electron density decreasing.The lysosomes in caudal part of spermatid swell earlier than the acrosomal system,and they are still being in maturation stage. A great number of spermatids have abnormal flagella,It is suggested that cloroquine:(1)elevates intralysosomal pH of spermatogenic cells,which inhibits metabolism of these cells,and rupture of lysosomes induces cell autolysis,(2)inhibits the activity of lysosomes in caudal part of spermatids,which is an important reason of flagellum dysplasia.

关 键 词：氯喹 生精细胞 溶酶体 顶体 精子 

分 类 号：R978.6[医药卫生—药品] R321.1[医药卫生—药学]