谷胱甘肽转移酶μ基因缺失与老年性白内障发病关系的探讨  

AstydtonrelationshipbetweenglutathioneS┐transferaseμgenedeletionandsenilecataractsuscepti┐bility

作　　者：皮静波[1,2] 白禹诗[1,2] 郑全美[1,2] 孙贵范[1,2] 

机构地区：[1]中国医科大学预防医学系保健科 [2]沈阳市眼病研究所

出　　处：《中华眼科杂志》1996年第3期224-226,共3页Chinese Journal of Ophthalmology

摘　　要：目的探讨谷胱甘肽转移酶μ（ｇｌｕｔａｔｈｉｏｎｅＳ－ｔｒａｎｓｆｅｒａｓｅμ，ＧＳＴμ）基因缺失与老年性白内障发病的关系。方法采用多聚酶链反应（ｐｏｌｙｍｅｒａｓｅｃｈａｉｎｒｅａｃｔｉｏｎ，ＰＣＲ）方法，对５９例老年性白内障患者及１１２例健康对照者进行ＧＳＴμ基因检测。结果老年性白内障患者ＧＳＴμ基因缺失率达６９．５％，明显高于对照组的５０．９％（Ｐ＜０．０５）。按吸烟与否分析表明，吸烟的白内障患者ＧＳＴμ基因缺失率有高于对照组的趋势。由于本研究样本量较小，吸烟的白内障患者ＧＳＴμ基因缺失率虽达到７２．４％，但与对照组比较差异无显著性（Ｐ＞０．０５）。结论老年性白内障的发病与ＧＳＴμ基因缺失密切相关，该基因缺失可能是个体易患白内障的遗传因素之一。ObjectiveTostudytherelationshipbetweenglutathioneS-transferaseμ(GSTμ)genedeletionandsenilecataract(SC)susceptibility.MethodPolymerasechainreaction(PCR)methodwasusedtoinvestigatetheratesofGSTμgenedeletionin59caseswithSCand112healthycontrols.ResultsTherateofGSTμgenedeletionincaseswithSCwas69.5%whichwassignificantlyhigherthanthatofthecontrols,50.9%(P<0.05).AnanalysisstratifiedbysmokingandnonsmokingshowedthatGSTμgenedeletionrateinsmokingsubjectswithSCwashigher.Becauseofthesmalsam-plesizeofthisstudy,althoughtherateofGSTμgenedeletioninsmokingsubjectswithSChasreached72.4%,thatisnotsignificantlydiferentfromthatofthecontrolsstatisticaly(P>0.05).ConclusionSCcorelateswithGSTμgenedeletionandGSTμgenedeletionisoneofthehereditaryfactorsforsus-ceptibilitytoSC.

关 键 词：谷胱甘肽转移酶类 基因 白内障 

分 类 号：R776.102[医药卫生—眼科]