铜、锌及铜氧化酶含量与肝豆状核变性的关系  

Connection Between the Content of Copper,Zinc,Copper-oxygenase and Wilson Disease

作　　者：杨慧平[1] 韩明璞 郭峰[2] 汪仁进 

机构地区：[1]杭州民生药业集团有限公司郑州办事处,河南郑州450003 [2]郑州大学第四附属医院,河南郑州450044

出　　处：《河南职工医学院学报》2005年第3期133-135,共3页Journal of Henan Medical College For Staff and Workers

摘　　要：目的探讨微量元素铜、锌及铜氧化酶含量与肝豆状核变性诊断及治疗转归的关系及临床意义。方法采用火焰原子吸收分光光度法测定肝豆状核变性患者的血清中微量元素铜、锌含量和尿中铜的含量;采用可见分光光度法测定铜氧化酶的含量。结果肝豆状核变性患者年龄为7～51岁(平均22.5±8.85岁),实验室检查和门诊初步诊断相比,铜氧化酶<0.21IU的确诊率为75.27%,血铜<10μmol·L-1的确诊率为66.67%,血锌<11.6μmol·L-1的确诊率为28.89%,治疗后尿铜含量差异非常显著(P<0.01)。结论血铜含量及铜氧化酶含量对肝豆状核变性确诊有良好的指导意义,尿铜含量可帮助医生对临床疗效转归和用药选择做出正确评价。Objective To explore the relationship and clinical meaning between trace chemical elements such as copper, zinc, copper-oxygenase and wilson （WD）, diagnosis and treatment. Methods The authors used flame atomic absorption spectrophotometry to measure the content of copper and zinc in WD sufferer＇ s serum and copper in urine, and the content of copper-oxygenase was determined by visible spectrophotometry. Results As to the WD sufferer＇ s outbreak aged in 7 - 51 （22.5 ± 8.85）, the laboratory check was comoared with policlic initiative and the diagnosis corresponding rate of copper-oxygenase was 〈 0.21IU 75.27 %, the diagnosis corresponding rate of copper was 〈 10umol/L 66.67%, the diagnosis corresponding rate of serum zinc was 〈 11.6umol/L 28.89%, there was statistically significant difference in the content of copper compard with the state before and after treatment（ P 〈 0.01 ）. Conclusion The content of serum copper and copper-oxygenase is of meaningful. The content assay of urine copper can help doctors choose drug and come to right evaluation.

关 键 词：铜 锌 铜氧化酶 含量测定 火焰原子吸收分光光度法 可见分光光度法 

分 类 号：R575.24[医药卫生—消化系统]