氟西汀增强三阶梯止痛治疗中晚期癌症疼痛的疗效观察  

Effect of Florentine for Enhancement of Three-step Ladder Analgesia for Patients with Advanced Cancer

作　　者：钱屹崟[1] 徐新才[1] 吴剑平[1] 柏卫青[1] 符炜[1] 王稹[1] 

机构地区：[1]常熟市第一人民医院肿瘤科,215500

出　　处：《实用癌症杂志》2005年第4期410-413,共4页The Practical Journal of Cancer

摘　　要：目的观察氟西汀在癌症疼痛的治疗中对三阶梯止痛治疗的增强作用以及对肿瘤患者生活质量及抑郁、焦虑状态的影响。方法60例伴有疼痛肿瘤患者随机分为A组(加用氟西汀治疗组)和B组(未加用氟西汀治疗组),每组30例。B组采用WHO三阶梯给药原则与方法,A组在此基础上加用氟西汀。用药6周后比较2组在疼痛缓解率、生活质量以及抑郁、焦虑状态方面的差异。结果A组与B组疼痛缓解率分别为83.30%和60.00%,两组比较有显著性差异(P<0.05);A组治疗后患者生活质量评分由68.79±3.16降至55.18±3.02,有显著性差异(P<0.05)。而B组生活质量评分治疗前后分别为69.67±3.10与68.18±2.84,治疗前后无显著性差异;A组治疗后其焦虑自测量表(SAS)与抑郁自测量表(SDS)评分明显降低。且应用后较少出现副作用。结论氟西汀用于肿瘤治疗可增强镇痛效果,提高肿瘤患者的生活质量,缓解患者的焦虑、抑郁状态,且副作用少。Objective To observe the effect of Florentine for enhancement of three-step ladder analgesia and its influence on quality of life（QoL） and stattis of depression and anxiety in patients with advanced cancer. Methods 60 patients with different cancer were derided randomly into two group to receive three-step ladder analgesia treatment（WHO）,combined with Florentine（group A,n = 30）, or without （group B, n = 30）. 6 weeks later, the pain relief rate, QoL and status of depression and anxiety were compared between the two groups. Results Pain relief rate in group A and group B was 83.30% and 60.00 % respectively,showing a significant difference（P 〈 0.05）. Scores of QoL showed a significant decrease（68.79 ± 3.16 to 55.18 ± 3.02） after treatment in group A（P 〈 0.05）, but not in group B（69.67± 3.10 to 68.18 ± 2.84）. Also the scores of self-rating depression scales（SDS） and self-rating anxiety seales（SAS） decreased markedly after treatment in group A. Fewer side-effects were observed in group A than in group B. Conclusion Fluoxetine can enhance the effect of analgesia for patients with advanced cancer with fewer complication. It can also improve the QoL and relieve the status of depression and anxiety of patients with cancer.

关 键 词：氟西汀 癌症 疼痛 三阶梯止痛 生活质量 抑郁 焦虑 

分 类 号：R730.53[医药卫生—肿瘤]