血清鳞癌抗原测定对肺癌诊断的意义  

Squamous Cell Carcinoma Antigen(SccAg)in the Diagnosis of Lung Cancer

作　　者：陈钦[1] 周新[1] 黄华瑞[1] 吴亚农[1] 

机构地区：[1]上海市第一人民医院呼吸科,上海市第一人民医院中心实验室

出　　处：《中国肿瘤临床》1996年第4期240-242,共3页Chinese Journal of Clinical Oncology

摘　　要：采用免疫放射法对４５例经临床及病理证实为肺癌患者及４１例其它呼吸系统疾病患者的血清鳞癌抗原（ＳｃｃＡｇ）进行测定。结果示肺癌组ＳｃｃＡｇ（＞１．５ｎｇ／ｍｌ）阳性率为６０％，非肺癌组为１４．６％（Ｐ＜０．０１）；其中，肺鳞癌最高为８９．５％，肺癌为１６．７％（Ｐ＜０．０５）。测定ＳｃｃＡｇ对肺癌诊断的敏感性为６０％，尤其是肺鳞癌为８９．５％；特异性为８５．４％。ＳｃｃＡｇ阳性率随肺癌病期进展而上升，Ⅱ、Ⅲ、Ⅳ期分别为５０％，６４．７％，８２．４％。本文结果表明测定血清ＳｃｃＡｇ值有助于肺癌，尤其是肺鳞癌的诊断，并可预示疾病的预后，若能结合其它肿瘤标记物及临床资料，则更有助于肺癌的诊断。The serum SccAg levels were measured by immunoradiometric assay in 45 patients with lung cancer,41 with other lung diseases.Serum SccAg was above 1.5ng/ml in 60% of patients with lung cancer and 14.6%of those with other lung diseases (P<0. 01)189.5% with lung squamous cell carcinoma and 16.7%with lung adenocarcinoma (P<0.05).In cases of lung cancer,the sensitivty rate was 60%(89.5% for squamous cell carcinoma)and specificity rate 85.4%.In lung cancer patients,the positivity rate of SccAg increased with progression of clinical stages(50%, 64.7%,82.4% for stageⅡ,Ⅲ,Ⅳ respectively).It is concluded that SccAg is useful in diagnosis of lung cancer,especially of squamous cell carcinoma and could be even more helpful provided being used in combination with other tumour markers and clinical findings as well.

关 键 词：鳞癌抗原 诊断 肺肿瘤 

分 类 号：R734.204[医药卫生—肿瘤]