胸腺瘤中Ⅳ型胶原分布的研究  

The Distribution of TypeⅣCollagen in Thymoma

作　　者：祁敏现 张云汉[1] 盛喜玲 高冬玲[1] 李惠翔[1] 郝志芳[1] 

机构地区：[1]河南省肺科医院,河南医科大学病理解剖教研室

出　　处：《中国肿瘤临床》1996年第4期260-262,共3页Chinese Journal of Clinical Oncology

摘　　要：采用Ⅳ型胶原抗体用ＬＳＡＢ免疫组化的方法对１８例胸腺瘤内Ⅳ型胶原阳性物质的分布进行观察研究。结果显示：皮质型胸腺瘤内Ⅳ型胶原阳性物质仅存在于间质、血管和血管周围间隙部位，肿瘤实质内则很少或无；而在髓质型胸腺瘤，肿瘤实质内可见弥散的Ⅳ型胶原阳性纤维存在，且纤维网络在几个或一团肿瘤细胞周围；在混合型胸腺瘤，上述两种类型均可出现。建议，此染色对胸腺瘤组织学分型及判断胸腺瘤的恶性程度方面均有一定意义。The distribution of typeⅣcollagen was studied in 18 cases of thymomas with LSAB immunohistochemical technics.The result showed that the fibers contained typeⅣcollagen were only present in the septa,blood vessel and perivascular space in cortical thymoma(CT).Diffuse intricate network of fibers that contained typeⅣcollagen surrounded a group of tumor cells in medullary thymoma(MT).In mixed thymoma(MxT)the above two staining patterns were observed.The authors believe that immunostaining for typeⅣcollagen was valuable in the assessment of histological type of thymoma and degree of malignancy.

关 键 词：胸腺瘤 Ⅳ型胶原 免疫组织化学 

分 类 号：R736.3[医药卫生—肿瘤]