胸腔灌注大剂量TNF治疗恶性胸水  

The Evaluation of High Dose TNF Instillation Intrapleurally in the Management of Malignant Pleural Effusion

作　　者：华新民[1] 吴清泽 段贵新[1] 徐力[1] 任宪伟[1] 刘建阳[1] 王启文[1] 卢卫平[1] 

机构地区：[1]吉林省肿瘤医院

出　　处：《中国肿瘤临床》1996年第4期263-265,共3页Chinese Journal of Clinical Oncology

摘　　要：２４例由组织学或／和细胞学诊断的恶性胸腔积液，经胸腔内灌注相当４倍机体最大耐受剂量（ＭＴＤ）的肿瘤坏死因子（ＴＮＦ４×１０６单位）进行治疗，ＣＲ１８例，ＰＲ４例，ＮＣ２例，有效缓解率９１．７％（２２／２４）。毒副反应：高热１６例（６６．７％），疼痛１４例（５８．３％），经对症处理可缓解。与其他胸水治疗方法比较，该方法具有疗效高，毒副反应低的特点。Twenty four cases with malignant pleural effusion confirmed either histologically or by cytology were treated by tumor necrosis factor(TNF)instillation 4 times the dosage of routine maximum tolerance dosage.CR was achieved in 18 cases,PR in 4 cases,NC in 2 cases. The overall response rate was 91.7%(22/24).Side reactions consisted of high fever in 16 cases(66. 7%),Chest pain in 14 cases (58.3%)which were relieved by appropriate measures.This approach of therapy was superior to other modalities of managements in terms of high efficacy and lower toxicity.

关 键 词：恶性胸腔积液 药物疗法 肿瘤坏死因子 

分 类 号：R730.53[医药卫生—肿瘤] R561.05[医药卫生—临床医学]