iNOS在大鼠正畸牙齿移动过程中牙周组织中的表达  

iNOS expression in the periodontal tissues in tooth movement in rat

作　　者：李伟宏[1] 吴立鹏[2] 赵刚[2] 

机构地区：[1]温州医学院附属口腔医院正畸科,浙江温州325000 [2]佳木斯大学附属口腔医院正畸科,黑龙江佳木斯154002

出　　处：《黑龙江医药科学》2005年第5期24-25,共2页Heilongjiang Medicine and Pharmacy

摘　　要：目的:观察诱导型一氧化氮合酶(induc ib le n itric ox ide syn thase,iNO S)在大鼠正畸牙齿移动过程中牙周组织改建过程中的表达,探讨NO/iNO S在正畸牙齿移动中的作用机制。方法:56只雄性W istar大鼠随机分为8组。正畸加力1、3、5、7、14、21、28d组和对照组分别进行HE和免疫组化染色、图像分析。结果:正畸加力3d后,牙周组织细胞iNO S表达增强,7d i-NO S表达达到高峰(P<0.01),以后iNO S表达下降。结论:NO/iNO S参与了正畸牙周组织改建过程,NO/iNO S可能参与了成骨过程。Objective： To observe the expression of inducible nitric oxide synthase （iNOS） in the orthodontic periodontal tissue remodeling, and study the role of NO/iNOS in the tooth movement in rats. Methods： Fifty-six male Wistar rats were randomly divided into 8 groups. Orthodontic appliance was placed between the maxillary right firstmolar and maxillary central incisors of rat. Immunohistochemistry and image analyses were performed at 0, 1,3, 5, 7, 14, 21,28 days after orthodontic force application. Results： The expression of iNOS showed weak immunoreactivities in normal periodotium. 3 days after the tooth movement, the immunoreactivities of iNOS were increased and at 7 days, reached the maximum. Conclusion： NO/iNOS participate in the orthodontic periodontal tissue remodeling in the tooth movement and NO/iNOS can promote the bone formation.

关 键 词：诱导型一氧化氮合酶 免疫组织化学 牙移动 

分 类 号：R783[医药卫生—口腔医学]