基于MEMS的微型药物控释系统释药特性研究  

Study of Release Traits of Subminiature Controlled Drug Release System Based on MEMS

作　　者：钱良山[1] 王小鹏[1] 陈天宁[1] 

机构地区：[1]西安交通大学机械工程学院,陕西西安710049

出　　处：《纳米科技》2005年第5期31-34,共4页

基　　金：国家“863”高技术研究发展项目（N0.2003AA404170）;国家自然科学基金资助项目（N0.50375116）

摘　　要：基于微纳米加工技术，设计一种可降解的植入式药物控释微载体，介绍利用紫外光刻（UV—LIGA）技术制备该类微载体的工艺。用聚羟基丙酸乙酸（PLGA）制作该微载体，分别对填充扑热息痛和扑尔敏两种药物的该类控释系统进行了实验研究，对比分析了在结构表面扎微孔和药物的溶解度对释药速率的影响情况，实验表明该类型微载体适用于植入式长期控释给药，而且累积给药量线性度较好。Based on the characteristics of micro/nano-fabrication technology a sort of implantable controlled drug release micro-cartier which might be biodegradable was designed, and the fabrication procedure by UV-LIGA technique was introduced. The micro-carriers were made with polymer （lactic-co-glycolic acid） （PLGA） packaged with Paracetamol and Chlorpheniramine. The role of micro-holes pricked on the surface of micro-carriers and the solubility of drugs to release drug were analyzed. Experimental results indicate that the micro-carriers represent a suitable dosage form for implantable long-term controlled drug release system with preferable linear release rates.

关 键 词：微载体 MEMS UV—LIGA PLGA 药物控释 

分 类 号：TP273[自动化与计算机技术—检测技术与自动化装置]