7-硝基吲唑对大鼠创伤性脑损伤早期脑水肿的影响  

Effect of 7-Nitroindazole on Early Cerebral Edema after Traumatric Brain Injury in Rats

作　　者：姜德华[1] 杜长军[1] 刘大跃[1] 刘洁[1] 

机构地区：[1]东南大学医学院附属徐州医院脑外科,江苏徐州221009

出　　处：《中国误诊学杂志》2005年第15期2806-2807,共2页Chinese Journal of Misdiagnostics

摘　　要：目的:探讨神经元型一氧化氮合酶(nNO S)在创伤性脑损伤(TB I)中的作用。方法:采用落体法大鼠TB I动物模型,观察特异性nNO S抑制剂7-硝基吲唑(7-N I)对TB I早期脑水肿和病理变化的影响。结果:与伤后6 h组相比,7-N I能显著减少脑组织含水量和脑组织中N a+的含量(P值均<0.05),而增加K+的含量(P<0.05),并能改善脑创伤后的病理变化。7-N I的作用可被L-精氨酸逆转,D-精氨酸无效。结论:nNO S来源的一氧化氮对TB I早期起毒性作用,nNO S抑制剂有可能成为治疗继发性脑损伤的新途径。Objective：To investigate the function of neuronal nitric oxide synthase （nNOS） in traumatric brain injury （TBI）. Methods：Using a rat model of focal cortical contusion according to Feeney,we studied the effect of nNOS inhibitor 7-nitroindazole（7-NI） on early traumatric cerebral edema and pathologicchange in cerebral cortex. Results ：Comparing with 6 hours after TBI group,administration of 7-NI significantly mitigated traumatric cerebral edema,and decreased the content of Na^＋ within brain （P〈0. 05 ,P〈0. 05 ,respectively） ,and increased the content of K^＋ （P〈0.05）. Histological examination showed that cortical contusion was improved treated with 7-NI. The effect of 7-NI was reversed by coadminstration of L-arginine, but not D arginine. Conclusion ： Nitric oxide derived from nNOS may act as a neurotoxic mediator in early traumatric brain injury, nNOS inhibitors may be used to treat secondary brain injury in future.

关 键 词：吲唑类/药物学 一氧化氮合酶/拮抗剂和抑制剂 脑损伤/并发症 脑水肿/药物疗法 7-硝基吲唑 创伤性脑损伤 损伤早期 脑水肿 神经元型一氧化氮合酶 大鼠 

分 类 号：R743.31[医药卫生—神经病学与精神病学] R651.15[医药卫生—临床医学]