Synthesis and in vino Antimalarial Activity of Several Simple Analogues of Peroxyplakoric Acid  

作　　者：LIU, He-Hua JIN, Hong-Xia ZHANG, Qi WU, Yi-Kang KIM, Hye-Sook WATAYA, Yusuke 

机构地区：[1]State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China [2]Faculty of Pharmaceutical Sciences, Okayama University, Tsuhima, Okayama 700-8530, Japan

出　　处：《Chinese Journal of Chemistry》2005年第11期1469-1473,共5页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202）, the Chinese Academy ot Sciences （“Knowledge Innovation”project, KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502） of China.

摘　　要：Several simple analogues of peroxyplakoric acid were synthesized by using Kobayashi＇s method to construct the key 1,2-dioxane core and tested in vitro for antimalarial activity. The scope and limitation of the method was also briefly examined.Several simple analogues of peroxyplakoric acid were synthesized by using Kobayashi＇s method to construct the key 1,2-dioxane core and tested in vitro for antimalarial activity. The scope and limitation of the method was also briefly examined.

关 键 词：PEROXIDES SPIROKETALS CYCLIZATIONS hemiketals 

分 类 号：TQ465[化学工程—制药化工]