An Efficient Enantioselective Synthesis of Blastmycinone  

作　　者：YANG, Yong-Qing wu, Yi-Kang 

机构地区：[1]State Key Laboratory of Bio-organic and Natural Products Chemistry, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 200032, China

出　　处：《Chinese Journal of Chemistry》2005年第11期1519-1522,共4页中国化学（英文版）

基　　金：Project supported by the National Natural Science Foundation of China （Nos. 20025207, 20272071, 20372075, 20321202）, the Chinese Academy of Sciences （Knowledge Innovation Project, No. KGCX2-SW-209）, and the Major State Basic Research Development Program （No. G2000077502）.

摘　　要：Blastmycinone, a degradation product of the antibiotic antimycin A, was synthesized with a TiCl4-mediated asymmetric aldolization as the key step. Some unexpected yet interesting chemistry was also observed.Blastmycinone, a degradation product of the antibiotic antimycin A, was synthesized with a TiCl4-mediated asymmetric aldolization as the key step. Some unexpected yet interesting chemistry was also observed.

关 键 词：LACTONE asymmetric synthesis ALDOL ACYLATION chiral auxiliary 

分 类 号：TQ465[化学工程—制药化工]