胶质瘤侵袭性的分子生物学机制  

Molecular Biological Mechanism of Glioma Invasion

作　　者：杨柳松[1] 胡锦[1] 

机构地区：[1]复旦大学附属华山医院神经外科,上海200040

出　　处：《中国神经肿瘤杂志》2005年第3期227-232,共6页Chinese Journal of Neuro-Oncology

摘　　要：胶质瘤是脑部最常见的肿瘤,目前治疗效果不佳。而肿瘤的侵袭性是其难以治愈的重要原因之一。本文通过对蛋白溶解酶、细胞表面粘附分子、生长因子及局部粘着斑激酶等细胞蛋白分子在肿瘤中的作用机理作一阐述,以了解与胶质瘤侵袭性相关的分子生物学机制。Glioma is the most common primary brain tumor, and the treatment efficacy has not been sut^eient yet till now. Tumor invasion is one of the important causes resulting its incurable. In this article, we summarize the role of proteases, cell surface adhesive molecule, grow factor, and FAK in glioma progress so that to reveal the molecular biological mechanism of glioma invasion.

关 键 词：胶质瘤 肿瘤侵袭 分子生物学 

分 类 号：R739.41[医药卫生—肿瘤]