XRCC1多态性与非吸烟女性肺腺癌易感性的关系  

Association of genetic polymorphism in DNA repair gene XRCC1 with risk of lung adenocarcinoma in nonsmoking women

作　　者：李鸣川[1] 尹智华[1] 崔泽实[2] 何钦成[1] 周宝森[1] 

机构地区：[1]中国医科大学流行病教研室,沈阳沈阳市卫生监督所110001 [2]中国医科大学实验技术中心,沈阳110001

出　　处：《中国肺癌杂志》2005年第5期431-434,共4页Chinese Journal of Lung Cancer

基　　金：美国中华医学基金会(00726)资助~~

摘　　要：背景与目的XRCC1是一种DNA损伤修复基因,其单核苷酸多态性异常是导致DNA修复能力个体差异的重要原因,可能导致个体患肺癌的危险升高。本研究的目的是探讨XRCC1单核苷酸多态性与非吸烟女性肺腺癌易感性的关系。方法采用以医院患者为基础的病例—对照研究方法,研究对象包括非吸烟女性肺腺癌患者126例和同期其它肺部疾病对照126例。以聚合酶链反应限制性片段长度多态性方法分析XRCC1基因Arg399Gln多态性,比较不同基因型与非吸烟女性肺腺癌的关系,并探讨油烟暴露与基因多态交互作用对患癌风险的影响。结果与携带399Arg/Arg基因型者比较,携带399Gln/Gln基因型者患肺腺癌的风险是其8.695倍(95%CI为3.343～22.614)。携带等位基因399Gln又有油烟暴露的个体患肺腺癌的风险明显增高,校正的比值比为5.21(95%CI为1.85～14.70,P<0.001)。结论XRCC1基因Arg399Gln多态性可能是非吸烟女性肺腺癌的遗传易感因素。Background and objective XRCC1 polymorphism at Arg399Gln site has been shown to modulate DNA repair capacity. The aim of this study is to assess the relationship between XRCC1 polymorphism and susceptibility to lung adenocarcinoma in nonsmoking female via a hospital-based case-control study. Methods Cases were 126 female patients with lung adenocarcinoma from January 2002 to October 2004 in China Medical University Hospital and Liaoning Tumor Hospital. Controls were selected from patients with other pulmonary diseases in the hospitals at the same time. These controls were matched to cases on age （±5 years）. Information concerning demographic and risk factors was obtained for each case and control by a trained interviewer. XRCC1 genotypes were determined by PCR RFLP. The adjusted odds ratio （OR） and 95% confidence interval （CI） were calculated using logistic regression. Results Cases showed a higher preva lence of oil smoke compared with controls （P〈0.05）. The frequencies of Arg/Arg, Arg/Gln and Gln/Gln in lung adenocarcinoma group （32.54%, 42.86%, 24.60%） were significantly different from those in controls （54.76%, 40.48%, 4.76%） （P〈0.05）. The individual carrying Gin/Gin genotype was at a significantly in creased risk of lung adenocarcinoma compared with those with Arg/Arg genotype （OR 8. 695, 95% CI3. 343-22. 614, adjusted for age and oil smoke exposure）. Furthermore, the OR of lung adenocarcinoma for the variant XRCC1 399Gln allele combined with exposure to oil smoke was 5. 21 （95%CI 1. 85-14. 70, P〈0. 001）. Conclusion The results indicate that the Arg399Gln polymorphism in XRCC1 is associated with the risk of lung adenocarcinoma in nonsmoking women.

关 键 词：女性肺腺癌 XRCC1基因 遗传多态性 

分 类 号：R734.2[医药卫生—肿瘤]