胃癌前哨淋巴结的临床研究  

Methylene blue and monoclonal antibody 3H11:in lymphatic mapping and sentinel lymph node biopsy in the pations with gastric cancer

作　　者：曹其彬 

机构地区：[1]山东省东营市人民医院普外科,山东东营257091

出　　处：《中国现代普通外科进展》2005年第1期45-47,共3页Chinese Journal of Current Advances in General Surgery

摘　　要：目的探讨胃癌前哨淋巴结(SLN)对预测各期胃癌淋巴结转移情况的意义。方法使用美蓝抗胃癌单克隆抗体MAb3H11,对120例胃癌术中及术后前哨淋巴结定位和活检。结果119例找到胃癌SLN为转移淋巴结,其中8例为唯一转移部位;55例SLN为非转移淋巴结,其中5例非前哨淋巴结存在转移。SLN预测胃周淋巴结转移的敏感性为928%,假阴性率为73%,准确率为958%。T1期敏感性100%,准确率100%;T2期敏感性963%,准确率979%;T3期敏感性为897%,准确率923%,假阴性率103%。结论胃癌SLN定位及活检技术能较准确反映早期胃癌的淋巴结转移状况。Objective： To identify the feasibility of lymphatic mapping and sentinel lymph node（SLN） biopsy and examine its accuracy in predicting the status of reaional lymphatio drainabe for different staaes of gastric cancer. Methods ： One hundred and twenty patients with gastric cancer intraoperativley and postoperatively underwent lymphhatic mapping and sentinel lymph node biopsy with methylene blue and monoclonal antibody（MAb） 3H11. Results：The SLNs were found in 119 of 120 pations,64 pations were found to have lymph node metastases in SLNs, 8 in SLNs alone;and 5 in nonSLNs alone. SLNs status could diaanose the lymph node status of the patient with sensitivity was 92. 75%, the accuracy of 95.8%. In T1 group, the sensitivity was 100%,accuracy was 1005;In T2 group, the sensitivity was 96.29%, accuracy was 97.92%; In T3 group,the sensitivity was 89.74%, accuracy was 92.31%. Conclusion ： The study confirmed that the procedure of lymphatic mapping and sentinel lymph node biopsy in the patients with gastric cancer is feasible. For early gastic cancer,the histologic of the SLN accurately predict the status of the patient.

关 键 词：胃肿瘤 亚甲蓝 前哨淋巴结活组织检查 淋巴转移 染色与标记 前哨淋巴结定位 早期胃癌 临床研究 胃周淋巴结转移 转移淋巴结 

分 类 号：R737.9[医药卫生—肿瘤] R735.2[医药卫生—临床医学]