子宫颈小细胞癌临床病理分析  

Small cell carcinoma of cervix: 3 cases report and review of literature

作　　者：张安民[1] 王啸[1] 

机构地区：[1]中国福利会国际和平妇幼保健医院病理科,上海200030

出　　处：《诊断病理学杂志》2005年第5期335-337,i0004,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨宫颈小细胞癌(SCCC)的临床病理特征、免疫组化特点和生物学行为。方法采用光镜、免疫组化对3例SCCC进行观察、随访,并复习相关文献。结果3例患者均表现为不同程度的不规则阴道出血。组织学显示肿瘤细胞小而圆,胞质少,核染色质深染,核仁不明显,分裂象活跃,可见坏死,肿瘤细胞呈片状浸润。其中2例合并鳞癌或腺癌。免疫组化示3例均表达至少2种神经内分泌标志(NSE、CHG_A、Syn)。治疗包括手术、放疗、化疗以及三者相结合。2例患者2年内均死于肿瘤转移。结论宫颈小细胞癌是一种少见的高度恶性肿瘤,具有独特的病理形态特征。免疫组化对诊断SCCC有一定帮助。SCCC侵袭性强,早期即发生转移,预后极差。Objective To investigate the clinicopathological features, carcinoma of the cervix （SCCC） and its behaviour. Methods Three cases of SCCC were investigated with light microscopy and immunohistochemical staining. Clinical follow-up was performed, and the related literature was reviewed. Results Blood spotting or abnormal vaginal bleeding was the most common clinical presentation. Histologically, the neoplastic cells appeared small round in solid sheets, scant cytoplasm, hyperchromatic, neclei and absence of nucleoli. Numerous mitotic figures and extensive necrosis were also common findings. The loci of squamous cell carcinoma or adenocarcinoma were identified in 2 cases. Immunohistochemical studies showed immunoreactivity for nettroendocrinic markers, such as NSE, CHG-A and Syn. Three patients stained positive for at least two neuroendocrine markers. Treatments included surgery, radiation, chemotherapy, or a combination of them. Two patients died of metastasis of carcinoma during follow-up of two years. Conclusions SCCC is a rare and highly malignant tumor with distinct pathological features. Immunohistological staining may be helpful in diagnosis of SCCC. It is aggressive with early metastases and has a poor prognosis.

关 键 词：宫颈肿瘤 小细胞癌 神经内分泌肿瘤 免疫组化 

分 类 号：R737.33[医药卫生—肿瘤]