VEGF-C及其受体VEGFR-3在不同级别脑星形细胞瘤中的表达  

Significance of expression of VEGF-C and VEGFR-3 in different histopathological grade of astrocytoma

作　　者：叶秀峰[1] 钟雪云[2] 米粲[1] 吴赤蓬[3] 

机构地区：[1]重庆医科大学病理学教研室,重庆400016 [2]暨南大学医学院病理学教研室,广州510632 [3]暨南大学医学院公共卫生学教研室,广州510632

出　　处：《诊断病理学杂志》2005年第5期365-367,i0013,共4页Chinese Journal of Diagnostic Pathology

基　　金：广东省科技厅研究团队项目课题(015012);广州市科技局科研重点立项课题(2001-E-01-2);国家科技部重大基础研究前期研究专项(2002ccc0400)

摘　　要：目的探讨血管内皮生长因子-C(VEGF-C)及血管内皮生长因子受体-3(VEGFR-3)在不同级别脑星形细胞瘤中的表达。方法检测50例不同级别脑星形细胞瘤患者手术切除标本中的VEGF-C和VEGFR-3的表达,并用抗FⅧ因子抗体标记瘤组织血管内皮细胞,计算肿瘤内微血管密度(IMVD)。结果VEGF-C和VEGFR-3阳性表达率分别为60%和52%。两者表达一致的符合率为74%。VEGF-C和VEGFR-3与脑星形细胞瘤病理分级呈显著正相关。结论脑星形细胞瘤中有VEGF-C和VEGFR-3的表达,其中VEGFR-3表达于血管。VEGF-C和VEGFR-3的表达与星形细胞瘤的病理分级相关。Objective To study the significance of expression of VEGF-C astrocytoma. Methods The Surgical specimens from 50 cases of brain and VEGFR-3 in different histopathological grade of astrocytoma were stained immunohistochemically for VEGF-C, VEGFR-3 and F Ⅷ. Intratumoral microvessed density （IMVD） was calculated by labeling the endothelial cells of the blood vessels within the tumor. Results VEGF-C and VEGFR-3 expression were found in 60% （30/50）, 52% （26/50）. VEGF-C, VEGFR-3 and FVIII expression was closely correlated with histopathological grades of astrocytoma. Conclusions VEGF-C and VEGFR-3 are presented in human brain astrocytoma. Blood vessels express VEGFR-3 positively in human astrocytoma. The expression of VEGF-C and VEGFR-3 is significantly associated with histopathological grade of astrocytoma.

关 键 词：星形细胞瘤 血管内皮生长因子-C 血管内皮生长因子受体-3 

分 类 号：R739.41[医药卫生—肿瘤]