脑胚胎发育不良性神经上皮瘤临床病理观察  

Clinicopathologic features of dysembryoplastic neuroepithelial tumor in brain

作　　者：宗阳如[1] 刘红潮[1] 车东媛[2] 

机构地区：[1]湖北省新华医院病理科,武汉430015 [2]华中科技大学同济医学院病理学教研室,武汉430030

出　　处：《诊断病理学杂志》2005年第5期373-375,i0016,共4页Chinese Journal of Diagnostic Pathology

摘　　要：目的探讨胚胎发育障碍性神经上皮瘤(DNT)的临床病理学特点及其鉴别诊断。方法观察1例DNT的组织学及免疫组化,并复习DNT文献。结果DNT多见于年轻人,以难治性癫为其主要临床特征,病理组织学检查,病变由多结节特异性胶质神经元和微囊细纤维黏液性基质等成分组成,同时伴有脑皮质的发育障碍,推测是DNT的组织发生基础。神经元细胞Syn、NF、NSE(+),胶质细胞GFAP和S-100蛋白(+)。结论DNT预后良好,手术切除后无需放、化疗,也无复发或恶性变。Objective To explore the clinicopathologic characteristics and observation of dysembryoplastic neuroepithelial tumor （DNT） and its differential diagnosis. Methods Apart from the review of DNT, a case of DNT was observed about its histopathology and immunohistochemistry. Results With the high appearance in youth, the DNT clinic presentation was intractable epilepsy. In histopathology, the lesions consisted of multinodular specific ghoneuronal elements in the mierocystic finely background mucinous matrix and assoiated with cortical dysplasia suggested a maldevelopmental origin. Well-differentiated neurons were randomly scattered in microcystoid space. Additionally, Syn and NF as well as NSE were also expressed in neurons. GFAP and S-100 protein were expressed in glial cells. Conclusion The prognosis of DNT is better after surgical operation without the needs of radiation or chemotherapy and it has no recurrence or malignant transformation.

关 键 词：DNT 胚胎发育障碍性神经上皮瘤 临床病理 

分 类 号：R735[医药卫生—肿瘤]