帕金森病基因治疗中病毒载体的研究进展  

The Reseach Advancement of Virus Vector in the Gene Therapy of Parkinson's Disease

作　　者：姚尧[1] 杜俊蓉[1] 

机构地区：[1]四川大学华西药学院药理教研室,四川成都610500

出　　处：《华西医学》2005年第4期797-798,共2页West China Medical Journal

摘　　要：帕金森病是一种神经节退行性疾病,主要以静止震颤,肌肉僵直和运动减少为临床症状。在其各种治疗方法中基因治疗最有望彻底治愈PD,最有发展前景。但其有效性与安全性与其所选用的载体有很大关系。本文介绍了基因治疗中常用的病毒载体以及它们的特性,并指出PD基因治疗中病毒载体的发展趋势。parkinson＇s disease （PD） is a degenerative disease of the basal ganglia causing tremor at rest, muscle rigidity and hypokinesia. Gene therapy is most likely to cure PD completely, and the most promising one among all the treating ways. But its effectiveness and safety have a strong relationship with the vectors chosed. This article introduces some usually used virus vectors and their characteristics as well as the trend of virus vector in PD＇ s gene therapy.

关 键 词：帕金森病'基因治疗 病毒 载体 

分 类 号：R742.5[医药卫生—神经病学与精神病学]