木樨草素对小鼠实验性溃疡性肠炎影响  

Effect of luteolin on ulcerative colitis in mice

作　　者：周祝成[1] 刘保林[1] 吴巍巍[1] 

机构地区：[1]中国药科大学中药药理教研室

出　　处：《中国临床药理学与治疗学》2005年第10期1152-1155,共4页Chinese Journal of Clinical Pharmacology and Therapeutics

摘　　要：目的：观察木樨草素对小鼠急性结肠炎的药效作用。方法：2，4-二硝基氯苯(DNCB)／乙醇灌肠制作小鼠急性结肠炎模型，灌肠给予木樨草素(1、10、50mg·kg^(-1))，考察木樨草素对小鼠结肠黏膜组织形态损伤，以及结肠组织髓过氧化物酶(MPO)活力和前列腺素E_2(PGE_2)含量等的影响。结果：DNCB诱发结肠炎后，小鼠出现腹泻、充血、溃疡、肠壁增厚等变化。灌肠给予木樨草素后，对小鼠的腹泻、组织损伤等有显著改善，并且能够降低结肠组织中MPO活性和pGE_2的含量。结论：木樨草素抑制炎性浸润、渗出和组织增生，减轻结肠黏膜的病理损害，对实验性动物急性结肠炎有较好的治疗作用。AIM： To evaluate the effect of luteolin on ulcerative colitis in experimental animals. METHODS： The mouse model of acute colitis was induced by instillation of dinitrochlorobenzene （ DNCB）/alcohol. Luteolin （1, 10 and 50 mg·kg^-1） were orally administrated to mice for 3 days. Diarrheas, colon weight index, macroscopic damage in the colon were observed and the activity of MPO and the content of PC, E2 in colon were also examined. RESULTS： The diarrhea and the colon weight index were reduced and the macroscopic damage in the inflammatory colon was effectively attenuated by luteolin. The elevated level of MPO and PGE2 were also significantly decreased. CONCLUSION： Luteolin can effectively inhibit the inflammatory infiltration, bleeding and proliferation in experimental ulcerative colitis.

关 键 词：木樨草素 溃疡性结肠炎 髓过氧化物酶(MPO) 前列腺素E2(PGE2) 

分 类 号：R965.1[医药卫生—药理学]